RUI: Acquisition of a 300 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for Undergraduate Chemical Research

有了这一重大研究仪器(MRI)计划的奖励，斯威特·布莱尔学院的化学系将获得一台300 MHz的核磁共振光谱仪。该设备将使研究人员能够开展以下方面的研究：a)结构-活性关系以及生物活性化合物类似物的合成和测试；b)天然产物的结构解析和表征；c)钯和铂生物活性化合物的新型配体的合成；d)二硫代磷酸寡核苷酸的合成和纯化，以及反义DNA在细胞培养中的活性测试。伦道夫-梅肯女子学院、霍林斯大学和维尔京群岛大学的教职员工也将可以使用这些设备。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对包括生物化学和药物开发在内的许多领域产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Sweet Briar College will acquire a 300 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) structure-activity relationship, and the synthesis and testing of analogs of bioactive compounds; b) structure elucidation and characterization of natural products; c) the synthesis of novel ligands for palladium and platinum bioactive compounds; and d) the synthesis and purification of dithiophosphate oligonucleotides, and the testing of activity in cell culture of antisense DNA. Faculty at Randolph-Macon Women's College, Hollins University and The University of the Virgin Islands will also have access to this equipment. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including biochemistry and drug development.