QuBIC: Novel DNA Nanostructures for Targeted Molecular Scale to Micron Scale Interconnects

QuBIC：用于靶向分子级至微米级互连的新型 DNA 纳米结构

• 批准号: 0218376
• 负责人: Thomas LaBean
• 金额: $ 35万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0218376&HistoricalAwards=false
• 关键词: QuBIC; Novel; DNA; Nanostructures; Targeted

EIA-0218376Thomas LaBeanDuke UniversityNovel DNA Nanostructures for Targeted Molecular Scale too Micron ScaleThe main thrust of this project is to develop fabrication techniques which bridge the gap between two size scales: (i) the micron scale, where conventional lithographic methods provide efficient top-down object construction, and (ii) the molecular scale, where viable bottom-up techniques for object assembly are beginning to emerge. The key problem addressed is how molecular scale structures can be selectively attached and interconnected with micron scale structures such that the molecular scale structures are functional. Bridging this gap is particularly important for advancing molecular-electronics into practical applications and for continuing the miniaturization trend of micro-electronics. This project approaches the scale gap challenge by the use of novel DNA nanostructures that have a scale between the two and can be made to selectively assemble with either. These structures present unique opportunities: (i) they provide for selective attachments via DNA annealing, (ii) they have length scales and flexibility permitting attachment to micron scale structures (iii) they can be metallized to provide conductive interconnects, (iv) potentially they can be used to orient other nanostructures such as carbon nanotubes. The major research steps to be taken include: (1) development of a diverse family of DNA nanostructures, (2) further characterization of existing DNA nanostructures, (3) further development of metallization techniques for these DNA nanostructures, (4) attachment experiments to various materials. The project impacts important educational objectives by providing training opportunities for science students at several educational levels. Funds are included for a high school student from the SEED project for under-represented minority students, as well as for a graduate student and half the salary of a post-doctoral fellow. Training of students at graduate and undergraduate levels is helping to create future scientists with strong interests in nanotechnology, DNA engineering, and related fields critical to continued growth in electronics and computer sciences.

EIA-0218376托马斯·拉贝杜克大学靶向分子尺度的新型DNA纳米结构微米尺度该项目的主要目标是开发制造技术，弥合两个尺寸尺度之间的差距：（i）微米尺度，其中传统的光刻方法提供有效的自上而下的物体构造，和（ii）分子尺度，其中可行的自下而上的物体组装技术开始出现。 解决的关键问题是如何将分子尺度结构选择性地与微米尺度结构连接和互连，使得分子尺度结构具有功能。 弥合这一差距对于推动分子电子学进入实际应用和继续微电子学的小型化趋势特别重要。 该项目通过使用新型DNA纳米结构来解决尺度差距的挑战，这种纳米结构具有介于两者之间的尺度，并且可以选择性地与任何一种组装。 这些结构提供了独特的机会：（i）它们通过DNA退火提供选择性附着，（ii）它们具有允许附着到微米级结构的长度尺度和柔性，（iii）它们可以被金属化以提供导电互连，（iv）潜在地它们可以用于定向其他纳米结构如碳纳米管。 主要的研究步骤包括：（1）开发一个多样化的DNA纳米结构家族，（2）进一步表征现有的DNA纳米结构，（3）进一步开发这些DNA纳米结构的金属化技术，（4）在各种材料上的附着实验。该项目通过为不同教育层次的理科学生提供培训机会，对重要的教育目标产生影响。 其中包括为代表人数不足的少数民族学生的SEED项目提供的一名高中生的经费，以及一名研究生的经费和一名博士后研究员的一半工资。 在研究生和本科生水平的学生的培训有助于创造未来的科学家在纳米技术，DNA工程，以及相关领域的浓厚兴趣，在电子和计算机科学的持续增长至关重要。