IRES: U.S.-Danish Cooperative Research and Education in DNA Nanotechnology

这项面向学生的国际研究体验（IRES）活动将北卡罗来纳州杜克大学的研究人员和导师与丹麦奥胡斯大学的同行联系起来。首席研究员Thomas H. LaBean和杜克大学的同事们将与由Kurt V. Gothelf领导的丹麦伙伴合作，管理一种平衡的、以团队为基础的纳米技术研究和教育方法。该综合合作项目将为美国研究生和本科生提供自组装DNA纳米结构和纳米化学方面的国际研究经验。杜克-奥胡斯IRES模式还包括博士后导师和准备进行研究的高中生。杜克大学的参与者将前往奥胡斯接受各种技术的培训，包括偶联化学和为未来实验使用的材料制备。每位初级参与者都将被分配项目，这些项目旨在为整个项目的研究目标和他们的专业发展做出贡献。这项IRES项目活动的技术重点反映了美国和丹麦的互补优势。计划中的跨学科工作要求具备合成化学、DNA结构工程、蛋白质生物化学、材料科学和分子生物学等方面的知识。杜克大学的团队在开发先进的DNA自组装方面贡献了自己的优势。奥胡斯团队在dna定向有机合成和偶联化学方面提供专业知识，用于将各种化合物偶联到寡核苷酸。通过互动，研究成果和培训经验将受益匪浅。总的来说，这种合作交流应该会产生结果，提高我们利用DNA自组装组织更广泛的纳米材料的能力，并利用复杂的DNA纳米结构编程复杂的纳米化学。IRES的教育价值在于学生参与导师的前沿研究，并接触到两所杰出机构的集体研究生活。美国-丹麦IRES在分子工程方面的合作实现了培养全球科学家和工程师的计划目标，使美国和欧洲的专家能够在共同感兴趣和有能力的领域结合互补的人才，分享研究和教育资源。更广泛的影响包括通过在丹麦卓越中心的一个研究项目，将美国初级研究人员和学生介绍给国际纳米技术社区的领导者。

This International Research Experience for Students (IRES) activity links researchers and mentors at Duke University in North Carolina with counterparts at the University of Aarhus in Denmark. Principal investigator, Thomas H. LaBean, and colleagues from Duke will work with Danish partners, led by Kurt V. Gothelf, to manage a balanced, team-based approach to research and education in nanotechnology. The integrated, collaborative program will provide international research experience for U.S. graduate and undergraduate students in self-assembling DNA nanostructures and nanochemistry. The Duke-Aarhus IRES model also involves post-doctoral mentors and research-ready high school students. Duke participants will travel to Aarhus to be trained in various techniques including conjugation chemistry and preparation of materials for use in future experiments. Each of the junior participants will be assigned projects that are designed to contribute to program-wide research goals as well as their professional development.The technical focus of this IRES program of activity reflects U.S.-Danish complementary strengths. The planned cross-disciplinary work requires knowledge of techniques in synthetic chemistry, DNA structural engineering, protein biochemistry, materials science, and molecular biology. Duke University's team contributes strengths in development of advanced DNA self-assemblies to the collaboration. The Aarhus team provides expertise in DNA-directed organic synthesis and conjugation chemistry for coupling diverse compounds to oligonucleotides. Research results and training experiences will benefit greatly through interaction. Overall, this cooperative exchange should yield results that improve our ability to organize a wider variety of nanomaterials using DNA self-assembly and program sophisticated nanochemistry using complex DNA nanostructures. The educational value of the IRES rests with the students' involvement in their mentors' cutting-edge research and exposure to the collective research life of two outstanding institutions. This U.S.-Danish IRES collaboration in molecular engineering fulfills the program objective of developing global scientists and engineers by enabling experts in the United States and Europe to combine complementary talents and share research and education resources in an area of strong mutual interest and competence. Broader impacts include the introduction of U.S. junior researchers and students to leaders in the international nanotechnology community through a program of study at an established Danish center of excellence.