Integrated Sensing: High-speed 3D Microscopy by Hybrid Optical-Digital Encoding and Processing

本提案的目标是开发一种高速，三维（3D）图像场景采集和渲染的新范式。该项目特别针对成像视频中的3D动态微观场景，可以通过立体显示系统以可变速度从多个视点离线进一步可视化。到目前为止，没有其他技术可以同时提供所提出系统的高时间和3d -空间分辨率。这种新型显微镜有望同时获得包含大景深、高分辨率和3d范围信息的图像。光数字系统基于一种新的方法，其中a)光学，b)数字计算和c)系统的呈现部分同时设计。该显微镜将首次结合旋转点扩展函数和波前编码技术。该系统将面向表面浮雕应用，其中非常快速的动态过程影响微观3D场景。特别是，它将进行MEMS检测测试。该系统在先进制造、远程显微镜信息共享、生物成像和其他需要高速获取和可视化3D微型场景映射的应用中，将是非常有价值的微纳模式识别和检查。研究生和本科生将积极参与分析、设计和实验。所开发的仪器将在随后的几年中用于显微镜可视化领域的教育。

The goal of this proposal is to develop a novel paradigm for high-speed,three-dimensional (3D) image scene acquisition and rendering. This projectis especially directed at imaging 3D dynamic microscopic scenes at videorates that can be further visualized off-line at variable speeds and frommultiple viewpoints with stereoscopic display systems. As of today, noother technique can offer simultaneously the high temporal and 3D-spatialresolution of the proposed system. The new microscope is expected toacquire images simultaneously containing large depth of field, highresolution, and 3D-range information.The optical-digital system is based on a novel approach in which a) theoptical, b) the digital computational, and c) the rendering parts of thesystem are simultaneously designed. The microscope will combine, for thefirst time, the rotating point-spread-function and the wavefront codingtechnologies. The system will be oriented to surface relief applicationswhere very fast dynamical processes affect the microscopic 3D scene. Inparticular, it will be tested for MEMS inspection.The proposed system will be extremely valuable in micro-nano patternrecognition and inspection for advanced manufacturing, remote microscopicinformation sharing, biological imaging, and other applications thatrequire the acquisition and visualization of 3D miniature scene-mappingsat very high speeds.Graduate and undergraduate students will be actively involved in theanalysis, design, and experiments. The instrumentation developed will beavailable for education in the area of microscopic visualization insubsequent years.