ALGORITHMS: Collaborative Research:Development of Vector Space based Methods for Protein Structure Prediction
算法:协作研究:基于向量空间的蛋白质结构预测方法的开发
基本信息
- 批准号:0305567
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-07-01 至 2008-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
What is novel and unique in this proposed research is the proposed design of knowledge-based prediction systems based on optimal vector space representations of proteins that have previously been represented by character strings. If an optimal representation of a character string can be found by a numerical sequence, then a great variety of methodologies from disciplines such as optimization, pattern discovery, and machine learning can be readily applied to new understanding of protein tertiary structure and function.For this, kernel based nonlinear classifiers and nonlinear dimension reduction as well as visualization methods will be developed to provide scalable and elective prediction systems.The prediction systems will be specially tailored for several problems related to protein structure discovery such as protein secondary structure, relative solvent accessibility and disulfide connectivity, as well as prediction of protein-protein interaction. In this proposal the P.I.s describe how they intend to accomplish this, so that their preliminary results can be extended to the more general structure and protein-protein interaction prediction problem. All results obtained will be made available to the research community in order to facilitate further research activity. Using existing web servers, the results will be made available to teaching faculty and graduate and undergraduate students in a suitable tutorial form. This will allow those interested to tailor the material for use in graduate and undergraduate research and class projects. The authors will incorporate the results into current and future course material as well.Special efforts will be made by the two women PIs to provide opportunities for womengraduate students to participate in the proposed research and for development of therelated software, which has long range social impact beyond the scientific results.
在这项研究中,新颖和独特的是基于知识的预测系统的设计,该系统基于先前由字符串表示的蛋白质的最佳向量空间表示。如果可以通过数字序列找到字符串的最佳表示,那么来自诸如优化、模式发现和机器学习等学科的各种各样的方法可以容易地应用于对蛋白质三级结构和功能的新理解。基于核的非线性分类器和非线性降维以及可视化方法将被开发,以提供可扩展的和可选择的预测预测系统将专门针对与蛋白质结构发现相关的几个问题,例如蛋白质二级结构,相对溶剂可及性和二硫键连接性,以及蛋白质-蛋白质相互作用的预测。在这个提议中,研究人员描述了他们打算如何实现这一目标,以便他们的初步结果可以扩展到更一般的结构和蛋白质-蛋白质相互作用预测问题。所获得的所有结果将提供给研究界,以促进进一步的研究活动。使用现有的网络服务器,结果将提供给教师和研究生和本科生在一个适当的教程形式。这将使那些有兴趣的人能够定制材料,用于研究生和本科生的研究和课堂项目。两位女研究员将特别努力为女研究生提供参与拟议研究和开发相关软件的机会,这些软件具有科学成果以外的长期社会影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Weili Wu其他文献
Using multi-features to recommend friends on location-based social networks
使用多功能在基于位置的社交网络上推荐朋友
- DOI:
10.1007/s12083-016-0489-5 - 发表时间:
2016-08 - 期刊:
- 影响因子:4.2
- 作者:
Xu-Rui Gao;Li Wang;Weili Wu - 通讯作者:
Weili Wu
EIF: A Mediated Pass-Through Framework for Inference as a Service
EIF:推理即服务的中介传递框架
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Yiming Gao;Zhen Wang;Weili Wu;Herman Lam - 通讯作者:
Herman Lam
Rumor Blocking in Social Networks
社交网络中的谣言拦截
- DOI:
10.1007/978-3-030-37775-5_4 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Wen Xu;Weili Wu - 通讯作者:
Weili Wu
Relationship between G-CSF and hyperleukocytosis in patients with APL after treatment with all-trans retinoic acid
全反式维A酸治疗后APL患者G-CSF与白细胞增多的关系
- DOI:
- 发表时间:
1999 - 期刊:
- 影响因子:0
- 作者:
G. Jiang;T. Tang;Guan;Yu;Wen Wu;Weili Wu;H. Ren;Liang - 通讯作者:
Liang
Breach-Free Sleep-Wakeup Scheduling for Barrier Coverage With Heterogeneous Wireless Sensors
- DOI:
doi:10.1109/TNET.2018.2867156 - 发表时间:
2018 - 期刊:
- 影响因子:
- 作者:
Zhao Zhang;Weili Wu;Jing Yuan;Ding-Zhu Du - 通讯作者:
Ding-Zhu Du
Weili Wu的其他文献
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{{ truncateString('Weili Wu', 18)}}的其他基金
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- 资助金额:
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NeTS:小型:协作研究:用于入侵检测的海底传感器网络:基础与实践
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1016320 - 财政年份:2010
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TF-SING:协作研究:以最低成本实现无线传感器网络部署的可靠时空覆盖
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0829993 - 财政年份:2008
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合作研究:KEYING SUITE - 用于传感器网络中密钥建立的协议库
- 批准号:
0627233 - 财政年份:2007
- 资助金额:
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Standard Grant
SGER: Optimization Problems in Next Generation Networks
SGER:下一代网络的优化问题
- 批准号:
0750992 - 财政年份:2007
- 资助金额:
-- - 项目类别:
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CompBio:Collaborative Research: Development of Effective Gene Selection Algorithms for Microarray Data Analysis
CompBio:合作研究:开发用于微阵列数据分析的有效基因选择算法
- 批准号:
0621829 - 财政年份:2006
- 资助金额:
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Continuing Grant
Efficient Spatial-Temporal Analysis of Environment and Public Health Related Data
环境和公共卫生相关数据的高效时空分析
- 批准号:
0513669 - 财政年份:2005
- 资助金额:
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Standard Grant
NSG: Studies in Optimizations with Applications
NSG:优化与应用研究
- 批准号:
0514796 - 财政年份:2005
- 资助金额:
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Standard Grant
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合作研究:CT-ISG:时间关键嵌入式系统的容错和安全基础设施
- 批准号:
0524429 - 财政年份:2005
- 资助金额:
-- - 项目类别:
Standard Grant
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