LCT Mass Spectrometer

LCT质谱仪

• 批准号: 0342701
• 负责人: James Jorgenson
• 金额: $ 18.36万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0342701&HistoricalAwards=false
• 关键词: LCT; Mass; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of North Carolina in Chapel Hill will acquire an LC time-of-flight mass spectrometer with atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) capabilities. This equipment will enhance research in a number of areas including a) discovery of new enantioselective dipolar cycloadditions from small ring heterocycles; b) combinatorial development of the catalytic asymmetric Aldol-Tischenko reaction; c) studies of pi-pi stacking interactions in small molecules and beta-turn peptides; d) chiral supramolecular assemblies and their applications in enantioselective processes; and e) biologically inspired studies in asymmetric catalysis. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including biochemistry and materials science.

凭借化学研究仪器和设施（CRIF）计划的这一奖项，位于查佩尔山的北卡罗来纳州大学化学系将获得一台具有大气压化学电离（APCI）和电喷雾电离（ESI）功能的LC飞行时间质谱仪。这一设备将加强若干领域的研究，包括：a）从小环杂环发现新的对映选择性偶极环加成反应; B）催化不对称Aldol-Tischenko反应的组合开发; c）小分子和β-转角肽中π-π堆积相互作用的研究; d）手性超分子组装及其在对映选择性过程中的应用;和e）在不对称催化中的生物启发研究。质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。这些研究的结果将对包括生物化学和材料科学在内的许多领域产生影响。