LCT Mass Spectrometer

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With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of North Carolina in Chapel Hill will acquire an LC time-of-flight mass spectrometer with atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) capabilities. This equipment will enhance research in a number of areas including a) discovery of new enantioselective dipolar cycloadditions from small ring heterocycles; b) combinatorial development of the catalytic asymmetric Aldol-Tischenko reaction; c) studies of pi-pi stacking interactions in small molecules and beta-turn peptides; d) chiral supramolecular assemblies and their applications in enantioselective processes; and e) biologically inspired studies in asymmetric catalysis. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including biochemistry and materials science.