RUI: Electrophilic Reactions of Triflic Acid and Chlorosulfonyl Isocyanate with Fluorosubstituted Terminal Alkenes

RUI：三氟甲磺酸和氯磺酰异氰酸酯与氟取代末端烯烃的亲电反应

• 批准号: 0345551
• 负责人: Dale Shellhamer
• 金额: $ 10.8万
• 依托单位: Point Loma Nazarene College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0345551&HistoricalAwards=false
• 关键词: RUI; Electrophilic; Reactions; Triflic; Acid

With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Program supports the research of Dr. Dale F. Shellhamer of the Department of chemistry at Point Loma Nazarene College. The research examines the regio- and stereochemistry of the addition of electron deficient species to alkenes substituted with one or more fluorine atoms. The investigations will blend synthetic and mechanistic chemistry in order to answer fundamental questions concerning the reactivity of organic fluorine-containing compounds. Since fluorinated organic compounds are important in contemporary medicine, industry and agriculture, knowledge of their diverse chemical behavior is quite important. In addition to adding mechanistic understanding, these studies will generate a new class of molecules that may prove useful in medicinal chemistry.With support from the Organic and Macromolecular Chemistry Program, Professor Shellhammer has designed research projects that can be accomplished by undergraduates after their sophomore year of chemistry. These students will synthesize a large number of fluoro organics, use modern instruments to characterize these compounds, and present their findings at weekly seminars. A major goal is to generate enthusiasm for science among undergraduates and prepare students for advanced study in graduate school. This innovative approach to undergraduate research will serve to challenge and prepare students as well as make significant contributions to organo fluorine chemistry.

有了这个本科院校研究（RUI）奖，有机和高分子计划支持博士戴尔F。Shellhamer说，他是Point Loma Nazarene学院化学系的教授。研究了缺电子物种与一个或多个氟原子取代的烯烃加成的区域和立体化学。调查将混合合成和机械化学，以回答有关有机含氟化合物的反应性的基本问题。 由于含氟有机化合物在现代医学、工业和农业中很重要，因此了解其不同的化学行为是非常重要的。除了增加机械的理解，这些研究将产生一类新的分子，可能证明在药物化学有用。从有机和高分子化学程序的支持下，教授Shellhammer设计了研究项目，可以由本科生完成后，他们的大二化学。 这些学生将合成大量的氟有机物，使用现代仪器来表征这些化合物，并在每周的研讨会上展示他们的发现。一个主要目标是激发本科生对科学的热情，并为学生在研究生院的深造做好准备。 这种创新的本科生研究方法将有助于挑战和准备学生，并为有机氟化学做出重大贡献。