SYNAPTA - Encoded synthesis, replication and evolution of unnatural nucleic acid therapeutics

SYNAPTA - 非天然核酸疗法的编码合成、复制和进化

• 批准号: 165239758
• 负责人: Professor Dr. Michael Famulok
• 金额: --
• 依托单位: Abteilung für Chemische Biologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/165239758?language=en
• 关键词: SYNAPTA; Encoded; synthesis; replication; evolution

Information storage and propagation in biological systems is based on just two types of nucleic acids, DNA and RNA. We are building an artificial genetic system based on a third type of genetic material (3NA) using orthogonal nucleic acid chemistry and evolved polymerases for the templated synthesis, replication and evolution of novel, sequence-defined nucleic acid polymers. Such a system will conclusively address questions such as the capacity of nucleic acid polymers other than DNA and RNA for information storage, heredity and evolution. Its application to the synthesis and evolution of nucleic acid therapeutics promises to address some of the systemic constraints inherent in DNA and RNA chemistry.

生物系统中的信息存储和传播仅基于两种类型的核酸，DNA和RNA。我们正在建立一个基于第三种类型的遗传物质（3NA）的人工遗传系统，使用正交核酸化学和进化的聚合酶，用于新型序列定义的核酸聚合物的模板合成，复制和进化。这样的系统将最终解决诸如DNA和RNA以外的核酸聚合物的信息存储、遗传和进化能力等问题。它在核酸治疗剂的合成和进化中的应用有望解决DNA和RNA化学中固有的一些系统性限制。