Physical Chemistry of Macromolecules as Probed by High Resolution Solid State NMR

本项目由耶鲁大学化学学部实验物理化学项目资助，由耶鲁大学的Kurt Zilm教授进行实验，开发固态核磁共振技术，用于固态大分子的结构测定和分析。这项工作旨在为蛋白质-配体相互作用、氢键和蛋白质折叠以及分子动力学在蛋白质折叠中的作用等领域提供基本的新见解。这些实验将有助于提供对生物分子结构和功能之间关系的更详细的理解，这将影响各种学科：从化学传感器的设计到环境友好化学的发展。该奖项将为参与的研究生提供一个机会，在化学和生物学的界面上进行研究。此外，该奖项将帮助Zilm教授继续他的工作，鼓励来自代表性不足群体的学生从事科学事业，并将丰富Zilm教授与当地K-12教师的专业发展活动。

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Kurt Zilm of Yale University will conduct experiments to develop solid-state nuclear magnetic resonance techniques for structure determination and analysis of large biomolecules in the solid state. The work is aimed at providing fundamental new insights into the areas of protein-ligand interactions, hydrogen bonding and protein folding, and the role of molecular dynamics in protein folding.These experiments will help to provide a more detailed understanding of the relationship between biomolecule structure and function, which should impact a variety of disciplines: from the design of chemical sensors to the development of environmentally benign chemistries. The award will provide an opportunity for the graduate students involved to pursue research that is at the interface of Chemistry and Biology. In addition, the award will help Prof. Zilm to continue his work encouraging students from underrepresented groups to embark on careers in science and will enrich Prof. Zilm's work in professional development activities with local K-12 teachers.