Physical Chemistry of Macromolecules as Probed by High Resolution Solid State NMR

高分辨率固态核磁共振探测大分子的物理化学

• 批准号: 0415829
• 负责人: Kurt Zilm
• 金额: $ 39.22万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415829&HistoricalAwards=false
• 关键词: Physical; Chemistry; Macromolecules; Probed; Resolution

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Kurt Zilm of Yale University will conduct experiments to develop solid-state nuclear magnetic resonance techniques for structure determination and analysis of large biomolecules in the solid state. The work is aimed at providing fundamental new insights into the areas of protein-ligand interactions, hydrogen bonding and protein folding, and the role of molecular dynamics in protein folding.These experiments will help to provide a more detailed understanding of the relationship between biomolecule structure and function, which should impact a variety of disciplines: from the design of chemical sensors to the development of environmentally benign chemistries. The award will provide an opportunity for the graduate students involved to pursue research that is at the interface of Chemistry and Biology. In addition, the award will help Prof. Zilm to continue his work encouraging students from underrepresented groups to embark on careers in science and will enrich Prof. Zilm's work in professional development activities with local K-12 teachers.

在这个由化学系实验物理化学项目资助的项目中，耶鲁大学的Kurt Zilm教授将进行实验，开发固态核磁共振技术，用于固态大生物分子的结构测定和分析。 这项工作旨在为蛋白质-配体相互作用、氢键和蛋白质折叠以及分子动力学在蛋白质折叠中的作用等领域提供基础性的新见解。这些实验将有助于更详细地了解生物分子结构和功能之间的关系，这将影响从化学传感器的设计到环境友好化学的开发等多个学科。 该奖项将为参与研究的研究生提供一个机会，从事化学和生物学接口的研究。 此外，该奖项将有助于Zilm教授继续鼓励来自代表性不足群体的学生从事科学事业，并将丰富Zilm教授与当地K-12教师的专业发展活动。