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PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES

PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
生物大分子物理化学
批准号：
2590282
负责人：
M S LEWIS
金额：
$0.0万
依托单位：
NATIONAL CENTER FOR RESEARCH RESOURCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/2590282
关键词：
CD40 molecule DNA repair HIV envelope protein gp120 T cell receptor analytical ultracentrifugation biophysics cell cycle proteins chemical structure function human immunodeficiency virus 1 human tissue integrase intermolecular interaction macromolecule mathematical model model design /development thermodynamics transcription factor

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中文摘要
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英文摘要
The purpose of this project is to study the physical properties of a wide variety of biological macromolecules and correlate these properties to the structure and function of the macromolecules. The emphasis is on the thermodynamics of the interactions of these macromolecules and on their molecular sizes and shapes. Analytical ultracentrifugation and mathematical modeling are the principal research techniques used. Among the associated systems studied have been the multifunctional chromagranins A and B, the cell cycle regulatory protein p53, T-cell receptors, DNA repair proteins, HIV-1 integrase, and CD4 binding to the C4 domain of HIV gp120.
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BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
  • 批准号：
    3916170
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    M S LEWIS
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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