PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES

这个项目的目的是研究一种 种类繁多的生物大分子，目标是 将这些属性与 大分子。重点放在原子的热力学上。 这些大分子的相互作用及其对分子大小的影响 和造型。分析超速离心法与数学 建模是使用的主要研究方法。 纤维蛋白原与其他蛋白质结合的研究 参与凝血和纤溶的工作仍在继续。 这一领域正在进行的研究涉及到 纤维蛋白原与血浆和血小板因子XIII及 纤溶酶原与血管紧张素转换酶D、E片段的相关性 纤维蛋白原。 对蓖麻毒素的研究涉及到对一种单抗的研究 对于蓖麻毒素B链，这种抗体与蓖麻毒素的相互作用， 以及它在体外和体内对蓖麻毒素毒性的影响。 对突触素的研究主要是为了确定 在这种自关联中涉及的反应的性质 蛋白。

The purpose of this project is to study the physical properties of a wide variety of biological macromolecules with the goal of correlating these properties to the structure and function of the macromolecules. The emphasis is on the thermodynamics of the interactions of these macromolecules and on their molecular size and shape. Analytical ultracentrifugation and mathematical modeling are the principal research techniques used. Studies on the association of fibrinogen with other proteins involved in blood clotting and fibrinolysis have been continued. Studies in progress in this area deal with the association of fibrinogen with plasma and platelet Factor XIII and with the association of plasminogen with the D and E fragments of fibrinogen. Research on ricin has involved studies on a monoclonal antibody to the ricin B chain, the interaction of this antibody with ricin, and its effect on ricin toxicity both in vitro and in vivo. Studies on synapsin have been directed toward determining the nature of the reactions involved in the self-association of this protein.