Equipment - An HPLC System with Multiple Detectors to Determine Molecular Morphology

设备 - 具有多个检测器的 HPLC 系统，用于确定分子形态

• 批准号: 0417640
• 负责人: Michael Mackay
• 金额: $ 8.11万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0417640&HistoricalAwards=false
• 关键词: Equipment; HPLC; System; Multiple; Detectors

Proposal No. CTS-0417640Principal Investigator: Michael E. Mackay, Michigan StateUniversity Equipment- An HPLC System with Multiple Detectors to Determine Molecular MorphologyThis equipment grant is for an advanced High Performance Liquid Chromatography (HPLC) system that will be used to characterize the molecular morphology of unique macromolecules. Molecular architecture is an important factor in producing nanoscale effects and is the thrust of several ongoing research topics in Prof. Mackay's laboratory. The system incorporates a multitude of detectors to determine the radius of gyration, hydrodynamic radius, molecular weight, intrinsic viscosity, second virial coefficient and concentration. From these molecular parameters it is possible to elucidate the molecular morphology. For example, the ratio of the radius of gyration and hydrodynamic radius is a powerful parameter related to the segment density distribution within a molecule to uniquely characterize it. This equipment will be used by graduate students and advanced undergraduate students as part of their research training. Prof. Mackay is developing a laboratory course, Nanoscale Characterization, and the HPLC system will also be used as part of this course. Other instruments within his laboratory will also be used including Atomic Force Microscopes and rheometers. The students will also take a trip to Argonne National Laboratory to perform a day of neutron scattering measurements as well as use the Scanning Electron Microscopes and Tunneling Electron Microscopes on campus. This will be a unique course and the students will perform characterization of samples on all the instruments to gain a fuller understanding of each instrument's capabilities.

提案编号 CTS-0417640 首席研究员：Michael E. Mackay，密歇根州立大学设备 - 具有多个检测器的 HPLC 系统，用于确定分子形态该设备拨款用于先进的高效液相色谱 (HPLC) 系统，该系统将用于表征独特大分子的分子形态。 分子结构是产生纳米级效应的重要因素，也是麦凯教授实验室正在进行的几个研究课题的主旨。 该系统包含多个检测器来确定回转半径、流体动力学半径、分子量、特性粘度、第二维里系数和浓度。 从这些分子参数可以阐明分子形态。 例如，回转半径与流体动力学半径之比是与分子内链段密度分布相关的重要参数，可以唯一地表征分子。 该设备将供研究生和高年级本科生使用，作为其研究培训的一部分。 Mackay 教授正在开发一门实验室课程“纳米级表征”，HPLC 系统也将作为该课程的一部分。 他实验室内的其他仪器也将被使用，包括原子力显微镜和流变仪。 学生们还将前往阿贡国家实验室进行一天的中子散射测量，并使用校园内的扫描电子显微镜和隧道电子显微镜。 这将是一门独特的课程，学生将在所有仪器上对样品进行表征，以更全面地了解每种仪器的功能。