Equipment - An HPLC System with Multiple Detectors to Determine Molecular Morphology

建议书编号CTS-0417640首席研究员：Michael E.Mackay，密歇根州立大学设备-一种带有多个检测器以确定分子形态的高效液相色谱系统这项设备拨款是为一种先进的高效液相色谱(HPLC)系统提供的，该系统将用于表征独特的大分子的分子形态。分子结构是产生纳米级效应的一个重要因素，也是麦凯教授实验室正在进行的几个研究课题的主旨。该系统集成了多个检测器来确定旋转半径、流体动力学半径、相对分子质量、特性粘度、第二维里系数和浓度。根据这些分子参数，可以阐明分子的形态。例如，旋转半径和流体动力学半径的比值是与分子内链段密度分布相关的一个强有力的参数，可以唯一地表征它。该设备将由研究生和高级本科生使用，作为他们研究培训的一部分。麦凯教授正在开发一门实验室课程，纳米尺度表征，高效液相系统也将作为这门课程的一部分使用。他实验室内的其他仪器也将被使用，包括原子力显微镜和流变仪。学生们还将前往阿贡国家实验室进行为期一天的中子散射测量，并在校园内使用扫描电子显微镜和隧道电子显微镜。这将是一门独特的课程，学生将对所有乐器的样品进行表征，以更全面地了解每种乐器的性能。

Proposal No. CTS-0417640Principal Investigator: Michael E. Mackay, Michigan StateUniversity Equipment- An HPLC System with Multiple Detectors to Determine Molecular MorphologyThis equipment grant is for an advanced High Performance Liquid Chromatography (HPLC) system that will be used to characterize the molecular morphology of unique macromolecules. Molecular architecture is an important factor in producing nanoscale effects and is the thrust of several ongoing research topics in Prof. Mackay's laboratory. The system incorporates a multitude of detectors to determine the radius of gyration, hydrodynamic radius, molecular weight, intrinsic viscosity, second virial coefficient and concentration. From these molecular parameters it is possible to elucidate the molecular morphology. For example, the ratio of the radius of gyration and hydrodynamic radius is a powerful parameter related to the segment density distribution within a molecule to uniquely characterize it. This equipment will be used by graduate students and advanced undergraduate students as part of their research training. Prof. Mackay is developing a laboratory course, Nanoscale Characterization, and the HPLC system will also be used as part of this course. Other instruments within his laboratory will also be used including Atomic Force Microscopes and rheometers. The students will also take a trip to Argonne National Laboratory to perform a day of neutron scattering measurements as well as use the Scanning Electron Microscopes and Tunneling Electron Microscopes on campus. This will be a unique course and the students will perform characterization of samples on all the instruments to gain a fuller understanding of each instrument's capabilities.