Modernization of the NMR Spectrometer Facility at the University of Mississippi Department of Chemistry and Biochemistry

密西西比大学化学与生物化学系核磁共振波谱仪设施的现代化

• 批准号: 0421319
• 负责人: Daniell Mattern
• 金额: $ 18万
• 依托单位: University of Mississippi
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0421319&HistoricalAwards=false
• 关键词: Modernization; NMR; Spectrometer; Facility; University

A grant has been awarded to the University of Mississippi under the direction of Dr. Daniell Mattern for partial support of the modernization of the Nuclear Magnetic Resonance Spectrometer facility in the Department of Chemistry and Biochemistry. The grant will enable the Department to refurbish its 13-year-old 300 MHz Nuclear Magnetic Resonance Spectrometer, replacing its console with a Linux-based workstation. Additional improvements include upgrades to the magnet control system, RF transmitter, and digital acquisition system, and the additions of console-controlled probe tuning, an automatic sample changer, and a variable temperature unit. Also, the console for the Department's other NMR instrument will be upgraded to a Linux-based workstation. The upgrades will greatly enhance the Department's ability to continue to operate these crucial Departmental workhorses.The majority of the Department's research groups depend on these two NMR instruments for routine analyses and/or for specialized molecular studies. Studies that will be facilitated by this grant include the synthesis and evaluation of polymeric electrolytes for fuel cell use and molecular-scale electrical rectifiers, the investigation of catalytic radical asymmetric cyclizations that can help make new organic molecules, the function of the crucial carboxylesterase enzymes, and how protein folding occurs and how it can affect gene expression. Concerning the Department's teaching mandate, NMR spectroscopy is a component of a wide variety of courses. These range from sophomore to graduate level laboratory courses and encompass a variety of sub-disciplines, including organic, inorganic, and biochemistry. The modernization will make the Bruker instruments much more accessible to undergraduate majors and graduate students.The NMR upgrade is also expected to provide broader impacts. It will assist the Department's recruitment and retention of minority students, at both the graduate level and through the University's Summer Research Institute for Undergraduates, which gives minority students from historically black colleges and universities laboratory research experience. Research projects assisted by the upgrade could benefit society by helping lead to the development of more efficient fuel cells, nanometer sized electrical devices, new routes to valuable pharmaceuticals, better antitumor agents, and new treatments for narcotics abuse.

在丹尼尔·马特恩博士的指导下，密西西比大学获得了一笔赠款，用于部分支持化学和生物化学系核磁共振光谱仪设施的现代化。这笔赠款将使该部能够翻新其已有13年历史的300兆赫核磁共振光谱仪，用一个基于Linux的工作站取代其控制台。其他改进包括对磁铁控制系统、射频发射机和数字采集系统的升级，以及增加了控制台控制的探头调谐、自动样品转换器和变温装置。此外，该部另一台核磁共振仪器的控制台将升级为基于Linux的工作站。这次升级将大大增强该部门继续运作这些关键工作的能力。该部门的大部分研究小组都依赖这两台核磁共振仪器进行常规分析和/或专门的分子研究。这笔赠款将促进的研究包括用于燃料电池和分子规模电子整流器的聚合物电解质的合成和评估，有助于制造新有机分子的催化自由基不对称环化的研究，关键的羧酸酯酶的功能，以及蛋白质折叠如何发生和如何影响基因表达。关于该系的教学任务，核磁共振光谱学是各种课程的组成部分。这些课程包括从二年级到研究生水平的实验室课程，包括各种子学科，包括有机化学、无机化学和生物化学。布鲁克仪器的现代化将使本科生和研究生更容易接触到布鲁克仪器。核磁共振的升级预计也将产生更广泛的影响。它将通过大学的本科生暑期研究所帮助该部在研究生一级和通过为来自历史上黑人学院和大学的少数族裔学生提供实验室研究经验的方式招聘和留住少数族裔学生。升级所协助的研究项目可以帮助开发更高效的燃料电池、纳米尺寸的电子设备、获得有价值的药物的新途径、更好的抗肿瘤药物以及治疗毒品滥用的新方法，从而使社会受益。