Collaborative Research: Metabolic Engineering of Saccharomyces cerevisiae for Enhanced Accumulation of Arsenic
合作研究:酿酒酵母代谢工程增强砷积累
基本信息
- 批准号:0422684
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-01 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DaSilva0422684The goal of this research is to metabolically engineer yeast cells for the adsorption of heavy metal arsenic. The idea is to manipulate the transporter genes for both import and export of the ionic form of the heavy metal, as well as manipulating the reduction system inside the cell. The proposed work will also utilize an integration system that the co-principal investigator has developed in her laboratory. This integration method allows the sequential integration of multiple cloned genes. Advantages of this system include the ability to insert precise numbers of the same or different genes (important for metabolic engineering) and integration at dispersed chromosomal locations, improving the stability of the insertions. The initial cloning effort will allow for some characterization for subsequent development of optimal strains for hyper accumulation of arsenic.
DaSilva 0422684本研究的目标是代谢工程酵母细胞吸附重金属砷。 这个想法是操纵转运基因来输入和输出离子形式的重金属,以及操纵细胞内的还原系统。 拟议的工作还将利用共同主要研究者在其实验室开发的集成系统。 这种整合方法允许多个克隆基因的顺序整合。 该系统的优点包括能够插入精确数量的相同或不同基因(对于代谢工程很重要)和整合在分散的染色体位置,提高插入的稳定性。 最初的克隆工作将允许一些表征,用于随后开发砷超积累的最佳菌株。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nancy Da Silva其他文献
Individual Differences in Attractiveness of Jobs Based on Compensation Package Components
- DOI:
10.1007/s10672-009-9141-3 - 发表时间:
2010-01-27 - 期刊:
- 影响因子:1.700
- 作者:
Lois E. Tetrick;Bart L. Weathington;Nancy Da Silva;Jennifer M. Hutcheson - 通讯作者:
Jennifer M. Hutcheson
Nancy Da Silva的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nancy Da Silva', 18)}}的其他基金
Collaborative Research: Data-driven engineering of the yeast Kluyveromyces marxianus for enhanced protein secretion
合作研究:马克斯克鲁维酵母的数据驱动工程,以增强蛋白质分泌
- 批准号:
2323983 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: NSF/MCB: Repurposing metabolite-responsive aptamers for real-time sensing and dynamic control of Cas6-mediated metabolon assembly
合作研究:NSF/MCB:重新利用代谢物响应适体,用于 Cas6 介导的代谢物组装的实时传感和动态控制
- 批准号:
2317399 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Data-driven engineering of the thermotolerant yeast Kluyveromyces marxianus
合作研究:耐热酵母克鲁维酵母的数据驱动工程
- 批准号:
2225877 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Synthetic CRISPR-Cas6 endonucleases for dynamic control of cellular phenotypes in yeast
合作研究:用于动态控制酵母细胞表型的合成 CRISPR-Cas6 核酸内切酶
- 批准号:
2013957 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: SusChEM: Engineering the thermotolerant yeast Kluyveromyces marxianus for the synthesis of biobased chemicals
合作研究:SusChEM:改造耐热酵母马克斯克鲁维酵母用于合成生物基化学品
- 批准号:
1803677 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: SusChEM: A Robust Yeast Platform for the Synthesis and Engineering of Polyketide-Based Pharmaceuticals and Chemicals
合作研究:SusChEM:用于聚酮化合物药物和化学品合成和工程的强大酵母平台
- 批准号:
1605357 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Exploiting synthetic GPCRs and mating factors as extracellular sensors for substrate-dependent assembly of complex cellulosomes
合作研究:利用合成 GPCR 和交配因子作为细胞外传感器,用于复杂多纤维素酶体的底物依赖性组装
- 批准号:
1263799 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Standard Grant
GOALI: Metabolic Engineering of Yeast for Polyketide Synthesis
目标:用于聚酮化合物合成的酵母代谢工程
- 批准号:
0432307 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Standard Grant
POWRE: Reusable Selection Cassettes for Gene Integration or Disruption in Mammalian Systems
POWRE:可重复使用的选择盒,用于哺乳动物系统中的基因整合或破坏
- 批准号:
9973438 - 财政年份:1999
- 资助金额:
-- - 项目类别:
Standard Grant
SGER: Advanced Ty-Mediated Integration Methods for Metabolic Engineering and Protein Production in Yeast
SGER:用于酵母代谢工程和蛋白质生产的先进 Ty 介导的整合方法
- 批准号:
9703527 - 财政年份:1997
- 资助金额:
-- - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
eMB: Collaborative Research: ML/AI-assisted environmental scale microbial nonlinear metabolic models
eMB:协作研究:ML/AI 辅助的环境规模微生物非线性代谢模型
- 批准号:
2325172 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Metabolic Bet-Hedging as a mechanism for the maintenance of functional diversity in tree-ectomycorrhizal mutualisms
合作研究:代谢下注对冲作为维持树外生菌根互利共生功能多样性的机制
- 批准号:
2316522 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
eMB: Collaborative Research: ML/AI-assisted environmental scale microbial nonlinear metabolic models
eMB:协作研究:ML/AI 辅助的环境规模微生物非线性代谢模型
- 批准号:
2325171 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Metabolic Bet-Hedging as a mechanism for the maintenance of functional diversity in tree-ectomycorrhizal mutualisms
合作研究:代谢下注对冲作为维持树外生菌根互利共生功能多样性的机制
- 批准号:
2316523 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: EDGE FGT: Development of a Comprehensive Selection Library to Reconcile Core Metabolic Knowledge Gaps
合作研究:EDGE FGT:开发综合选择库以弥合核心代谢知识差距
- 批准号:
2319733 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: EDGE FGT: Development of a Comprehensive Selection Library to Reconcile Core Metabolic Knowledge Gaps
合作研究:EDGE FGT:开发综合选择库以弥合核心代谢知识差距
- 批准号:
2319732 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
eMB: Collaborative Research: ML/AI-assisted environmental scale microbial nonlinear metabolic models
eMB:协作研究:ML/AI 辅助的环境规模微生物非线性代谢模型
- 批准号:
2325170 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Detecting Gait Phases with Raised Metabolic Cost using Robotic Perturbations and System Identification for Enabling Targeted Rehabilitation Therapy
合作研究:使用机器人扰动和系统识别来检测代谢成本升高的步态阶段,以实现有针对性的康复治疗
- 批准号:
2203144 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Metabolic habitat barriers imposed on tropical diel vertical migrators
合作研究:对热带昼夜垂直迁徙者施加的代谢栖息地障碍
- 批准号:
2127524 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Detecting Gait Phases with Raised Metabolic Cost using Robotic Perturbations and System Identification for Enabling Targeted Rehabilitation Therapy
合作研究:使用机器人扰动和系统识别来检测代谢成本升高的步态阶段,以实现有针对性的康复治疗
- 批准号:
2203143 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Standard Grant