Ovarian Follicle Selection Mediated by Release from Inhibitory Map Kinase Signaling
抑制图谱激酶信号释放介导的卵巢卵泡选择
基本信息
- 批准号:0445949
- 负责人:
- 金额:$ 47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-02-01 至 2009-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In reproductively active vertebrate females that ovulate a limited number of eggs each ovulatory cycle, it is the rate-limiting process of ovarian follicle selection that ultimately determines the number of competent follicles eventually capable of being fertilized. Vertebrate follicle selection currently represents an incompletely defined process by which an undifferentiated follicle is activated to undergo final differentiation in preparation for ovulation, whereas the likely fate of those follicles not selected is follicle death. In the hen ovary, the ovulation of a single follicle per day requires an existing preovulatory hierarchy which normally consists of a limited number of fully differentiated follicles. This follicle hierarchy is maintained by the daily 'selection' of a single follicle from a small group of undifferentiated (prehierarchal) follicles measuring 6 to 8 mm in diameter. The novel hypothesis of the research proposed is that the selection of a single, prehierarchal follicle per day into the preovulatory hierarchy is first dependent upon the release of the follicle granulosa layer from inhibitory signaling, and subsequently dependent upon an increased sensitivity to Follicle-Stimulating Hormone. A central hypothesis tested herein is that the release from inhibitory Mitogen Activated Protein Kinase signaling is prerequisite for follicle selection in the avian ovary. Furthermore, it is proposed that such MAPK signaling is promoted by the local production of one or more members of the epidermal growth factor (EGF) family of peptides. The present project describes experiments using the hen ovary model system to study endocrine, novel paracrine and autocrine factors, together with their associated membrane receptors, that tightly regulate follicle selection and subsequent differentiation. Collectively, results from the study will determine critical cellular and molecular processes that define follicle selection (and by implication reproductive potential) in a vertebrate species. Interpretations of these data are predicted to pertain to all groups within the Sauropsid lineage (e.g., oviparous reptiles, crocodiles and birds) in which the establishment of an ovarian follicle hierarchy is prerequisite for egg laying. The PI has established a record of providing teaching and research training to graduate and undergraduate students of diverse backgrounds, and is committed to the professional development of female students. The PI is an ongoing participant in the Department's REU Summer Fellows Program that serves under-represented populations, and he routinely incorporates his related research expertise into his academic lecture and laboratory curricula.
在每个排卵周期排卵数量有限的生殖活跃的脊椎动物雌性中,卵巢卵泡选择的速率限制过程最终决定了最终能够受精的合格卵泡的数量。脊椎动物卵泡选择目前代表了一个不完全定义的过程,通过这个过程,未分化的卵泡被激活,进行最终分化,为排卵做准备,而那些未被选择的卵泡可能的命运是卵泡死亡。在母鸡卵巢中,每天一个卵泡的排卵需要一个现有的排卵前等级,该等级通常由有限数量的完全分化的卵泡组成。这种卵泡等级是通过每天从一小群直径为6至8毫米的未分化(分级前)卵泡中“选择”一个卵泡来维持的。该研究提出的新假设是,每天选择一个卵泡进入排卵期前的卵泡首先取决于卵泡颗粒层从抑制信号中释放出来,随后取决于对促卵泡激素的敏感性增加。本文检验的一个中心假设是,抑制丝裂原活化蛋白激酶信号的释放是鸟类卵巢卵泡选择的先决条件。此外,研究人员提出,这种MAPK信号是由表皮生长因子(EGF)家族肽的一个或多个成员的局部产生促进的。本项目描述了利用母鸡卵巢模型系统研究内分泌、新型旁分泌和自分泌因子及其相关的膜受体,这些因子密切调节卵泡选择和随后的分化。总的来说,研究结果将确定脊椎动物卵泡选择(以及生殖潜力)的关键细胞和分子过程。据预测,对这些数据的解释适用于蜥脚类动物谱系中的所有类群(如卵生爬行动物、鳄鱼和鸟类),其中卵泡等级的建立是产卵的先决条件。学院为不同背景的研究生和本科生提供教学和研究培训,并致力于女学生的专业发展。PI是该部门REU夏季研究员计划的持续参与者,该计划服务于代表性不足的人群,他经常将他的相关研究专业知识纳入他的学术讲座和实验室课程。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alan Johnson其他文献
The Kinsey data: Marginal tabulations of the 1938-1963 interviews conducted by the Institute for Sex Research
金赛数据:性研究所 1938 年至 1963 年访谈的边缘表格
- DOI:
- 发表时间:
1979 - 期刊:
- 影响因子:0
- 作者:
P. Gebhard;Alan Johnson;A. Kinsey - 通讯作者:
A. Kinsey
The Greater Flamingo
更大的火烈鸟
- DOI:
10.5040/9781472596918 - 发表时间:
2008 - 期刊:
- 影响因子:1.3
- 作者:
Alan Johnson;F. Cézilly - 通讯作者:
F. Cézilly
Molecular characterisation of common Culicoides biting midges (Diptera: Ceratopogonidae) in Ireland
- DOI:
10.1186/s13071-025-06754-7 - 发表时间:
2025-04-23 - 期刊:
- 影响因子:3.500
- 作者:
Elsie Isiye;Angela Valcarcel Olmeda;Thomas Curran;David O’Neill;Theo de Waal;Gerald Barry;Aidan O’Hanlon;James O’Shaughnessy;Nicole Keohane McCarthy;Akke Vellinga;Audrey Jenkinson;Alan Johnson;Damien Barrett;Sarah Costello;Annetta Zintl;Denise O’Meara - 通讯作者:
Denise O’Meara
Project-Based Learning in Leisure Management Training
休闲管理培训中的项目式学习
- DOI:
10.1007/978-94-017-1388-7_12 - 发表时间:
1998 - 期刊:
- 影响因子:0
- 作者:
Alan Johnson;T. Snaith - 通讯作者:
T. Snaith
Influence Of High Molecular Weight Factor VIII On The Expression Of Factor VIII Procoagulant Activity
高分子量因子VIII对因子VIII促凝血活性表达的影响
- DOI:
10.1055/s-0038-1652746 - 发表时间:
1981 - 期刊:
- 影响因子:6.7
- 作者:
Alan Johnson;M. Soberano;Steven Kowalski;Anne Fulton;V. Macdonald;Martin Semar - 通讯作者:
Martin Semar
Alan Johnson的其他文献
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{{ truncateString('Alan Johnson', 18)}}的其他基金
Collaborative Research: Implementing Topologically Protected Gigahertz Acoustic Circuits
合作研究:实现拓扑保护的千兆赫声电路
- 批准号:
2221326 - 财政年份:2022
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
EFRI 2-DARE: Functionalized Monolayer Heterostructures for Biosensors with Optical Readout
EFRI 2-DARE:用于具有光学读出功能的生物传感器的功能化单层异质结构
- 批准号:
1542879 - 财政年份:2015
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
Follicle Selection and Differentation in the Avian Ovary
鸟类卵巢中的卵泡选择和分化
- 批准号:
1354713 - 财政年份:2014
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
AIR Option 2: Research Alliance Bio-enabled Nanosensors with Fully Programmable Ligand Detection
AIR 选项 2:具有完全可编程配体检测功能的研究联盟生物纳米传感器
- 批准号:
1312202 - 财政年份:2013
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
I-Corps: Pilot Production Of Large Area Uniform Single-Crystal Graphene Films
I-Corps:大面积均匀单晶石墨烯薄膜的中试生产
- 批准号:
1158721 - 财政年份:2011
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
International: Student Exchange for Research on Nano/Biotechnology
国际:纳米/生物技术研究学生交换
- 批准号:
1130994 - 财政年份:2011
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
Cellular Determinants of Granulosa Cell Differentiation in Avian Ovarian Follicles
禽类卵巢卵泡颗粒细胞分化的细胞决定因素
- 批准号:
0968784 - 财政年份:2009
- 资助金额:
$ 47万 - 项目类别:
Continuing Grant
NSEC on Molecular Function at the Nano/Bio Interface
NSEC 探讨纳米/生物界面的分子功能
- 批准号:
0832802 - 财政年份:2009
- 资助金额:
$ 47万 - 项目类别:
Cooperative Agreement
Cellular Determinants of Granulosa Cell Differentiation in Avian Ovarian Follicles
禽类卵巢卵泡颗粒细胞分化的细胞决定因素
- 批准号:
0841204 - 财政年份:2009
- 资助金额:
$ 47万 - 项目类别:
Continuing Grant
Graphene- and Metal-based Atomically Precise Nanoelectronics
基于石墨烯和金属的原子级精确纳米电子学
- 批准号:
0805136 - 财政年份:2008
- 资助金额:
$ 47万 - 项目类别:
Standard Grant
相似海外基金
Mechanism of follicle selection in mammalian ovary- Is the selection induced by inhibin?
哺乳动物卵巢中卵泡选择的机制——选择是由抑制素诱导的吗?
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