Fabrication of High Aspect Ratio Optical/Electrochemical Hybrid Sensor Arrays

高纵横比光学/电化学混合传感器阵列的制造

• 批准号: 0518293
• 负责人: David Walt
• 金额: $ 42万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0518293&HistoricalAwards=false
• 关键词: Fabrication; Aspect; Ratio; Optical; Electrochemical

Professor David Walt of Tufts University is supported by the Analytical and Surface Chemistry Program to create a microsensor platform that can make simultaneous electrochemical and optical measurements. The major objective is to demonstrate the feasibility of performing multiplexed analysis using electrochemiluminescence (ECL). The PI has pioneered the use of random optical arrays for multiplexed analysis. In this project, the PI is creating a hybrid optical and electrochemical sensor array by deposition of gold in micron-diameter, open silica capillaries, which also function as optical fibers. Optical microbeads will be prepared, inserted into wells in the fibers and excited by an electropotential applied through the microwires. The resulting emitted light will be collected through the fiber. The beads are coated with conducting polyaniline or polypyrrole so that they can be functionalized to detect various species. The long-term goal involves the creation of a universal platform in which either optical or electrochemical (or both types of) sensors can be interrogated individually in an array format. The coupling of electrochemistry and spectroscopy increases the amount of information that can be obtained from a given sensor, preventing false positives. There is a great need for next generation sensors that can detect numerous species accurately and inexpensively. The integrated platform being created in this project will allow applications in the clinical, environmental and chemical and bioprocess control areas. The array platform should enable new types of chemical imaging measurements with micrometer spatial resolution, which could be used in medical diagnostics and the study of biological cells. This research exposes students to several disciplines including chemistry, optics, physics and biology.

塔夫茨大学的大卫·沃尔特教授得到了分析和表面化学计划的支持，创建了一个可以同时进行电化学和光学测量的微传感器平台。主要目的是论证使用电化学发光(ECL)进行多路分析的可行性。PI开创了使用随机光学阵列进行多路分析的先河。在这个项目中，PI正在通过在微米直径的开放的二氧化硅毛细管中沉积金来创建混合光学和电化学传感器阵列，这些毛细管也可以用作光纤。将制备光学微珠，将其插入光纤中的井中，并通过微线施加的电势进行激励。由此产生的发射光将通过光纤被收集。珠子上涂有导电聚苯胺或聚吡咯，这样它们就可以功能化，以检测各种物种。长期目标包括创建一个通用平台，其中光学或电化学(或这两种类型)传感器可以以阵列格式单独进行询问。电化学和光谱学的结合增加了可以从给定传感器获得的信息量，防止了假阳性。人们迫切需要能够准确且廉价地检测大量物种的下一代传感器。该项目正在创建的综合平台将允许在临床、环境以及化学和生物过程控制领域进行应用。该阵列平台应能够实现微米空间分辨率的新型化学成像测量，可用于医疗诊断和生物细胞研究。这项研究让学生接触到几个学科，包括化学、光学、物理和生物。