Cracking the LIM-code: Transcription factor networks in developmental biology

破解 LIM 密码：发育生物学中的转录因子网络

• 批准号: DP0985020
• 负责人: Prof Jacqueline Matthews
• 金额: $ 30.16万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-28 至 2012-11-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985020
• 关键词: Cracking; LIM; code; Transcription; factor

Our current inability to stimulate the regeneration of nervous tissue is frustrated by a lack of detailed knowledge of the complex processes that take place at the molecular and cellular levels during development. We are determining how a group of cellular proteins that have key roles in neural development interact with each other and with DNA. With this information we are developing reagents that can be used to probe the fundamental process of cell differentiation in the central nervous system.

我们目前无法刺激神经组织的再生，这是由于缺乏对发育过程中在分子和细胞水平上发生的复杂过程的详细了解而造成的。我们正在确定一组在神经发育中起关键作用的细胞蛋白质如何相互作用以及与DNA相互作用。有了这些信息，我们正在开发可用于探测中枢神经系统细胞分化基本过程的试剂。