Dissecting a hematopietic transcription factor complex

剖析造血转录因子复合物

• 批准号: DP0343385
• 负责人: Prof Jacqueline Matthews
• 金额: $ 18.85万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0343385
• 关键词: Dissecting; hematopietic; transcription; factor; complex

The development of mature active cells is a highly complex and coordinated process that is controlled largely by groups of interacting regulatory proteins. We are trying to understand, at a very detailed level, how a specific group of these proteins interact to regulate both normal blood cell development and the onset of childhood leukemias. Using this information we will try to develop reagents that can be used to inhibit these interactions and be used as lead compounds for treatments for disease.

成熟活性细胞的发育是一个高度复杂和协调的过程，主要由相互作用的调节蛋白群控制。我们正试图在一个非常详细的层面上了解，这些特定的蛋白质群是如何相互作用来调节正常血细胞的发育和儿童白血病的发病的。利用这些信息，我们将尝试开发可用于抑制这些相互作用的试剂，并将其用作治疗疾病的先导化合物。