LIM-homeodomain interactions in neuronal development

神经元发育中的 LIM-同源域相互作用

• 批准号: DP0663289
• 负责人: Prof Jacqueline Matthews
• 金额: $ 23万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-05-02 至 2009-05-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663289
• 关键词: LIM; homeodomain; interactions; neuronal; development

The loss of central nervous system function, through accident or disease, is devastating for affected individuals and their families. Our current inability to stimulate the regeneration of nervous tissue is a result of the lack of detailed knowledge of the complex processes that must take place, at the molecular and cellular levels, during neuronal development. We are determining how a group of cellular proteins that have key roles in motor neuron development interact with each other and with DNA. With this information we are developing reagents that can be used to further probe central nervous system function and may ultimately be used to regenerate damaged nerves.

由于事故或疾病而导致的中枢神经系统功能丧失，对受影响的个人及其家庭来说是毁灭性的。我们目前无法刺激神经组织的再生是由于缺乏对神经发育过程中必须在分子和细胞水平上发生的复杂过程的详细了解。我们正在确定一组在运动神经元发育中起关键作用的细胞蛋白质如何相互作用以及与DNA相互作用。有了这些信息，我们正在开发可用于进一步探测中枢神经系统功能的试剂，并可能最终用于再生受损的神经。