Inhibiting protein-protein interactions involved in neural development and disease

抑制神经发育和疾病中涉及的蛋白质-蛋白质相互作用

• 批准号: DP110104332
• 负责人: Prof Jacqueline Matthews
• 金额: $ 29.56万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-03-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110104332
• 关键词: Inhibiting; protein; interactions; involved; neural

This project will determine the molecular mechanisms by which the protein LMO4 (a regulator of brain development) binds to DEAF1 (which also regulates neural development) and CtIP (which protects against tumour formation). This will allow a set of reagents to be developed to help determine the functions of LMO4, and may ultimately be used to treat disease.

该项目将确定蛋白质LMO4（大脑发育的调节剂）与DEAF1（也调节神经发育）和CtIP（防止肿瘤形成）结合的分子机制。这将允许开发一套试剂来帮助确定LMO4的功能，并最终用于治疗疾病。