Protein-protein interactions in the transcriptional regulation of neural development

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Combinations of transcription factor protein regulate the expression of genes, but just how different combinations of these proteins specifically up or down regulate specific genes is poorly understood. This project will focus on the LIM-homeodomain transcription factors, which act in combination to form the so-called "LIM code" that specifies cell type specification during development. Using a series of biophysical and structural approaches. This project will unravel the networks of protein-protein interactions that form the basis of the LIM code. This will help address a major issue in the field: How do interactions between transcription factors regulate DNA-binding specificity. Ultimately, this work may also lead to regeneration of nerve tissue.