An Ultrasensitive Biosensor Integrating Semiconductor Nanowires with Plasmonic Resonators

一种将半导体纳米线与等离子体谐振器集成的超灵敏生物传感器

• 批准号: 0701703
• 负责人: Leigh Smith
• 金额: --
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0701703&HistoricalAwards=false
• 关键词: Ultrasensitive; Biosensor; Integrating; Semiconductor; Nanowires

0701703Leigh M. Smith, University of CincinnatiAn Ultrasensitive Biosensor Integrating Semiconductor Nanowires with Plasmonic ResonatorsIntellectual Merit: The goal of this research is to harness optical nonlinearities in semiconductor nanowires and metal plasmonic resonators to create a novel nanoscale biosensor. The proposed biosensor will synergistically combine these two powerful effects in semiconductor and metallic nanostructures to develop an extremely sensitive self-contained sensor for detecting specific biopathogens such as bacteria, viruses and toxins. Functionally, attachment of a pathogen to a metallic nanostructure will cause it to come into resonance with an exciting laser, thereby causing large photocurrents in a one-dimensional semiconductor nanowire. This project will lead to an understanding of both the fundamental and the technical issues involved in each component of this sensor in order to fabricate a portable device with arrays of nanowires, each sensitized for a specific pathogen. Such a handheld device could be used by local health officials, by law enforcement officials, by doctors in their offices, and by the producers or processors of our food supply. Broader Impacts: The proposed research benefits society, since the rapid and sensitive detection of pathogens or toxins will improve our homeland security as well as the safety of our water and food supply. The proposed research project will also have great impact on preparing our nation's future scientists. The involvement and training of graduate students, postdoctoral fellows as well as undergraduate students in interdisciplinary work involving semiconductor nanostructure science and engineering provides needed talent for this growing segment of the nation's workforce and, on the individual level, provides the sort of training necessary to be successful in these jobs. These researchers will also work to excite young people about science through an annual Saturday Nanoscience Day for area middle school students and their teachers.

[07017 . 03] leigh M. Smith，美国辛辛那提大学集成半导体纳米线和等离子体谐振器的超灵敏生物传感器智能优势：本研究的目标是利用半导体纳米线和金属等离子体谐振器中的光学非线性来创建一种新型纳米级生物传感器。所提出的生物传感器将在半导体和金属纳米结构中协同结合这两种强大的效应，开发出一种非常敏感的自包含传感器，用于检测特定的生物病原体，如细菌、病毒和毒素。从功能上讲，将病原体附着在金属纳米结构上将使其与激发激光发生共振，从而在一维半导体纳米线中产生大的光电流。这个项目将导致对传感器每个组件的基本和技术问题的理解，以便制造一个带有纳米线阵列的便携式设备，每个纳米线对特定的病原体敏感。这种手持设备可以被地方卫生官员、执法官员、医生在他们的办公室以及我们食品供应的生产商或加工商使用。更广泛的影响：拟议的研究有利于社会，因为病原体或毒素的快速和敏感的检测将改善我们的国土安全以及我们的水和食物供应的安全。拟议的研究项目也将对培养我国未来的科学家产生重大影响。研究生、博士后和本科生在涉及半导体纳米结构科学和工程的跨学科工作中的参与和培训，为这一日益增长的国家劳动力提供了所需的人才，并且在个人层面上，提供了在这些工作中取得成功所必需的培训。这些研究人员还将通过为地区中学生和他们的老师举办的一年一度的周六纳米科学日，努力激发年轻人对科学的兴趣。