bvcxzu+Sqwynthesis of Functional Composite Nanofibers Templated by 1D Self-assembly of Tobacco Mosaic Virus

知识专长：本计画以烟草花叶病毒为模板，开发出一种建构复合奈米导线与纤维的方法。 TMV是一种杆状病毒，在适当的pH和离子强度条件下，其倾向于进行头-尾结合。 因此，其作为用于形成具有高纵横比和均匀直径的纳米线和/或纳米纤维的模板是有吸引力的。 在这项工作中，将导致许多单体材料结合到TMV模板上，之后它们将聚合成共价连接的线和纤维。 概念验证通过结合和聚合简单的有机碱苯胺来证明。 另外提出的单体包括亚乙基二氧噻吩，其可以预期产生具有比聚苯胺高得多的电导率的聚合物。 这样的结构可以用于构建纳米级电路和其他纳米器件。 导电纤维（线）不是唯一寻求的种类。 纤维状无机结构可以例如通过在温和的酸性条件下用四乙氧基硅烷涂覆TMV以产生长二氧化硅/TMV复合纤维来制备。 由于有机和无机单体单元可以制备成具有各种化学和物理特性，因此可以希望获得具有所需电、光或磁特性的TMV模板化纤维。 单体与模板的结合可以通过静电力、氢键力或其他力来稳定，这取决于单体的特性。 这项工作的主要重点将是了解控制各种单体类型沿着TMV模板组装的基本因素。 此外，还将重点关注使用显微镜、电导率、X射线散射和纳米力学测量对聚合纳米结构进行仔细表征。 可以预期用于制备具有期望的机械、化学和物理特性的纳米纤维和纳米线的廉价的通用方法对于各种纳米器件的构造具有广泛的适用性。 该提案包括一项计划，通过为期一周的生物纳米粒子技术夏季研讨会吸引高中生和大学生从事科学职业。 它还为研究生和本科研究生的跨学科培训提供了一个平台。

INTELLECTUAL MERIT: This project develops a method for constructing composite nanoscale wires and fibers using tobacco mosaic virus (TMV) as a template for assembly. TMV is a rod-like virus that has a tendency to undergo head-to-tail association under suitable conditions of pH and ionic strength. It is therefore attractive as a template for the formation of nanowires and/or nanofibers with a high aspect ratio and uniform diameter. In this work a number of monomeric materials will be caused to bind to the TMV template after which they will be polymerized into covalently linked wires and fibers. Proof of concept was demonstrated by binding and polymerizing the simple organic base aniline. Additional proposed monomers include ethylenedioxythiophene which can be expected to yield a polymer with considerably higher conductivity than polyaniline. Such structures could be useful in constructing nanoscale circuitry and other nanodevices. Conductive fibers (wires) are not the only species sought. Fiber-like inorganic structures can be prepared, for example, by coating TMV with tetraethoxysilane under mild acid conditions to produce long silica/TMV composite fibers. Because the organic and inorganic monomer units can be prepared with a variety of chemical and physical characteristics, one can hope to obtain TMV-templated fibers with desired electrical, optical, or magnetic properties. Binding of monomers to the template may be stabilized by electrostatic, hydrogen-bonded, or other forces, depending on the character of the monomer. The primary focus of the work will be to understand the fundamental factors that govern assembly of various monomer types along the TMV template. Significant attention will also be given to careful characterization of the polymerized nanostructures using microscopy, conductance, X-ray scattering, and nanomechanical measurements.BROADER IMPACTS: An inexpensive, general method for preparing nanofibers and nanowires possessing desired mechanical, chemical, and physical characteristics can be expected to have broad applicability for the construction of various nanodevices. The proposal includes a plan for attracting high school and university students into scientific careers through a week-long Summer Workshop for Bionanoparticle Technology. It also provides a platform for interdisciplinary training of graduate and undergraduate research students.