Materials World Network: US-Russia Collaboration on Responsive Micelles at Surfaces -- A Combined Experimental and Theoretical Approach

材料世界网络：美俄在表面响应胶束方面的合作——实验与理论相结合的方法

• 批准号: 0710591
• 负责人: Svetlana Sukhishvili
• 金额: --
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0710591&HistoricalAwards=false
• 关键词: Materials; World; Network; US; Russia

This Materials World Network project is a combined theoretical and experimental study of novel polymer films which contain block copolymer micelles (BCMs) whose micellar structure will be designed to respond to external stimuli. The project brings together an international team of researcher-theoreticians from the Department of Physics at Moscow State University, Russia (MSU) with their expertise in polymer theory, and a research group at Stevens Institute of Technology (US) with their expertise in synthesis, self-assembly and characterization of thin polymer films at surfaces. The use of stimuli-responsive BCMs, whose cores can be used to carry cargo, in combination with layer-by-layer (LbL) self-assembly is a new approach which is explored in this project. BCM-containing multilayers are able to carry and release large amounts of functional molecules in response to temperature or pH variations. The Russian group develops novel theoretical strategies based on weak and strong segregation approaches, a theory of reversible association-dissociation and a Random Phase Approximation (RPA) method to elucidate the structure of BCM in BCM/polyelectrolyte multilayer (PEM) films. The US group (1) synthesizes novel pH- and temperature-responsive block copolymers which contain zwitterionic groups in the micellar corona, (2) studies self-assembly of BCMs of these copolymers with a linear polyelectrolyte using LbL approach and (3) characterizes micellar structure and morphology in self-assembled films before and after application of environmental stimuli. In situ phase modulated ellipsometry and neutron reflectivity are applied to access the structure and molecular conformations in micelle-containing films. In situ ATR-FTIR and in situ AFM measurements also allow local ionization changes within the film and the strength of intermolecular binding and chain relaxations to be related to film morphology and response. The research yields guidelines for the construction of BCM/PEM films and, in a broader sense, reveals major polymer structure-property relationships as applied to polymer self-assembly at surfaces. The development of BCM/PEM materials will meet a yet unmet need for environmentally triggerable polymer films which, through changes in their structure, can efficiently regulate the delivery of drugs, cosmetic compounds or fragrances.A significant feature of this collaboration is strong emphasis on education and exchange of faculty personnel and graduate students between the Russian and US labs. Visits of graduate students to MSU with the purpose of integrating theoretical and experimental knowledge of responsive BCM/PEM films in an international setting, exchange of teaching practices, enhancement of an international student exchange by participation of US students in an annual Student Conference on polymers and polymer films in Russia are planned. The US group will further disseminate the knowledge obtained during international exposure to undergraduate and high-school students. This award is co-funded with the Office of International Science and Engineering..

该材料世界网络项目是对新型聚合物薄膜的理论和实验研究相结合，该薄膜包含嵌段共聚物胶束（BCM），其胶束结构将被设计为对外部刺激做出反应。该项目汇集了来自俄罗斯莫斯科州立大学（MSU）物理系的研究人员-理论家组成的国际团队，他们在聚合物理论方面具有专业知识，史蒂文斯理工学院（美国）的一个研究小组，他们在表面聚合物薄膜的合成，自组装和表征方面具有专业知识。使用刺激响应的BCM，其核心可用于运载货物，结合逐层（LbL）自组装是本项目探索的一种新方法。含有BCM的多层膜能够响应于温度或pH变化而携带和释放大量的功能分子。该俄罗斯小组基于弱分离和强分离方法、可逆缔合-解离理论和随机相近似（RPA）方法开发了新型理论策略，以阐明BCM/聚电解质多层（PEM）膜中BCM的结构。美国研究小组（1）合成了新型的pH和温度响应性嵌段共聚物，其胶束冠中含有两性离子基团，（2）使用LbL方法研究了这些共聚物的BCM与线性胶束的自组装，（3）表征了环境刺激前后自组装膜中的胶束结构和形态。原位相位调制椭圆偏振法和中子反射率法被用来研究胶束膜的结构和分子构象。原位ATR-FTIR和原位AFM测量还允许膜内的局部电离变化和分子间结合和链松弛的强度与膜形态和响应相关。该研究产生的指导方针，用于构建的PETS/PEM膜，并在更广泛的意义上，揭示了主要的聚合物结构-性能的关系，适用于聚合物自组装在表面。这种聚合物薄膜通过改变其结构，可以有效地调节药物、化妆品化合物或香料的输送。这种合作的一个重要特点是非常重视俄罗斯和美国实验室之间的教师和研究生的教育和交流。研究生访问MSU的目的是在国际环境中整合响应性聚合物/PEM薄膜的理论和实验知识，交流教学实践，通过美国学生参加俄罗斯聚合物和聚合物薄膜年度学生会议来加强国际学生交流。美国小组将进一步向本科生和高中生传播在国际接触中获得的知识。 该奖项由国际科学与工程办公室共同资助。