New mechanisms of DNA recognition by zinc-finger domains

锌指结构域识别DNA的新机制

• 批准号: DP0984726
• 负责人: Prof Joel Mackay
• 金额: $ 29.12万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-05-01 至 2012-09-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984726
• 关键词: New; mechanisms; DNA; recognition; zinc

The work described in this proposal carries long-term benefits to the health of Australians. Many debilitating diseases, including many varieties of cancer, arise as a result of a breakdown in the normal regulation of gene transcription. It is only once we have a thorough understanding of transcriptional regulation in normal organisms that we will be in a position to devise effective therapies to deal with the disorders that result from aberrant gene expression. Our proposed research program also provides the opportunity to train younger scientists in state-of-the-art molecular and structural biology, thus representing a significant national benefit.

这项提案中描述的工作为澳大利亚人的健康带来了长期的好处。许多令人衰弱的疾病，包括许多种类的癌症，都是由于基因转录的正常调控崩溃而产生的。只有当我们对正常生物体的转录调控有了透彻的了解，我们才能设计出有效的治疗方法来处理由基因异常表达引起的疾病。我们建议的研究计划还提供了培训年轻科学家最先进的分子和结构生物学的机会，因此代表着重大的国家利益。