The design of targetable epigenetic modifiers

可靶向表观遗传修饰剂的设计

• 批准号: DP160104106
• 负责人: Prof Joel Mackay
• 金额: $ 31.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104106
• 关键词: design; targetable; epigenetic; modifiers

The project aims to engineer enzymes as valuable tools for understanding gene expression mechanisms and potentially a technology for altering gene expression in plants, animals or humans in a targetable manner. The genetic information encoded in the DNA of all complex organisms has been shown to be augmented by decorations on both DNA and the histone proteins that package DNA. This so-called epigenetic information is important but not well understood. The project plans to design highly specific and targetable enzymes that can interrogate and manipulate epigenetic information in living cells. Understanding the regulation of gene expression and controlling the expression of chosen genes may form a foundation for applications in agriculture, biology and medicine.

该项目旨在将酶作为理解基因表达机制的有价值的工具，并有可能成为一种以可靶向的方式改变植物、动物或人类基因表达的技术。所有复杂生物体DNA中编码的遗传信息已被证明可以通过DNA和包装DNA的组蛋白上的修饰来增强。这种所谓的表观遗传信息很重要，但尚未得到很好的理解。该项目计划设计高度特异性和可靶向的酶，可以询问和操纵活细胞中的表观遗传信息。了解基因表达的调控和控制选定基因的表达可能为农业、生物学和医学的应用奠定基础。