The regulation of gene expression by post-translational modification of transcription factors

转录因子翻译后修饰对基因表达的调控

• 批准号: DP120104137
• 负责人: Prof Joel Mackay
• 金额: $ 36.94万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-03-09 至 2015-03-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120104137
• 关键词: regulation; gene; expression; post; translational

Different cells in the body express different subsets of our genes, and it is not well understood how cells know which genes to switch on and which to switch off in a given situation. We will investigate the way in which chemical tags are put onto and removed from the molecules that control gene expression in order to direct their function.

体内不同的细胞表达不同的基因子集，目前还不清楚细胞是如何知道在特定情况下打开哪些基因，关闭哪些基因的。我们将研究化学标签被置于控制基因表达的分子上和从其上移除以指导其功能的方式。