Uniting histone and transcription factor codes

联合组蛋白和转录因子代码

• 批准号: DP180103785
• 负责人: Prof Joel Mackay
• 金额: $ 41.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103785
• 关键词: Uniting; histone; transcription; factor; codes

This project aims to establish the general features of the “histone code”. It is well established that gene expression patterns are determined in part by the deposition, recognition and removal of post-translational modifications on the histone proteins that package eukaryotic DNA. This project proposes that this "histone code" is in fact a specific example of a transcription factor code. The project aims to enhance our understanding of the mechanisms underlying gene regulation in plants and animals, and help to create improved strategies to optimise crop and farm animal properties and new-generation therapeutics.

本项目旨在建立“组蛋白密码”的一般特征。众所周知，基因表达模式在一定程度上是由包装真核DNA的组蛋白上的沉积、识别和去除翻译后修饰决定的。这个项目提出，这个“组蛋白代码”实际上是转录因子代码的一个具体例子。该项目旨在加强我们对植物和动物基因调控机制的理解，并帮助制定改进的策略，以优化作物和农场动物的特性和新一代治疗方法。