Collaborative Research: Evolutionary and Ecological Physiology of Blue Mussels (genus Mytilus): Gene and Protein Expression and Molecular Evolution in Differently Adapted Congeners

合作研究：蓝贻贝（贻贝属）的进化和生态生理学：不同适应同类中的基因和蛋白质表达以及分子进化

• 批准号: 0717087
• 负责人: Lars Tomanek
• 金额: --
• 依托单位: California Polytechnic State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0717087&HistoricalAwards=false
• 关键词: Collaborative; Research; Evolutionary; Ecological; Physiology

The distribution patterns and sensitivities to climate change of different species will be affected by their tolerance of environmental stress. This project will characterize the physiological processes in native and invasive species of blue mussels (genus Mytilus) that are most critical in the animal''s responses to changes in temperature and salinity, on a scale from minutes to weeks and even to generations. This work is the first application of modern genome-enabled technologies (transcriptomics - the study of gene expression, and proteomics - identification of proteins present in a cell) to describe the dynamics of thousands of genes and proteins simultaneously in marine animals subjected to environmental stress. In addition, this project will compare gene sequences and protein structure and function to identify the characteristics of proteins that determine the species'' different tolerance limits. This project has many broader impacts. These studies will examine why an invasive blue mussel species from the Mediterranean Sea has successfully replaced the native blue mussel along the southern portion of the Pacific Coast of North America. The blue mussels to be studied are of great interest to researchers in ecology, marine science, and evolutionary biology, as well as to State and Federal natural resource managers who seek to understand the environmental impacts of climate change on natural populations and the processes by which invasive species succeed in new habitats. The results will be of special significance to the "Mussel Watch" Project, which uses mussels to monitor the water quality status of coastal and estuarine waters. The collaboration between Stanford University and California Polytechnic State University, San Luis Obispo, brings together students from all stages of training, from high school students to postdoctoral researchers, in an effort to foster a socially and ethnically diverse research environment. Cross-campus exchanges will facilitate an excellent learning environment for students at both campuses.

对不同物种的气候变化的分布模式和敏感性将受到对环境压力的耐受性的影响。 该项目将表征蓝贻贝（Mytilus属）中的生理过程，这些过程在动物对温度和盐度变化的反应中，在几分钟到几周甚至几代人的范围内都至关重要。 这项工作是现代基因组技术的第一个应用（转录组学 - 基因表达的研究和蛋白质组学的研究 - 鉴定存在于细胞中的蛋白质），以同时描述受环境压力的海洋动物中数千种基因和蛋白质的动力学。 此外，该项目将比较基因序列和蛋白质结构和功能，以确定确定物种“不同耐受限制的蛋白质的特征”。 该项目具有许多更广泛的影响。 这些研究将研究为什么来自地中海的侵入性蓝贻贝物种成功地取代了北美太平洋海岸南部沿线的本地蓝贻贝。 生态学，海洋科学和进化生物学的研究人员以及寻求了解气候变化对自然种群的环境影响的州和联邦自然资源经理的研究人员以及侵入性物种在新栖息地中成功的过程。 结果对“贻贝手表”项目具有特殊意义，该项目使用贻贝监测沿海和河口水的水质状态。 斯坦福大学和加利福尼亚理工大学圣路易斯·奥比斯波（San Luis Obispo）之间的合作汇集了从高中生到博士后研究人员的各个培训阶段的学生，以促进社会和种族多元化的研究环境。 跨校园交流将为两个校园的学生提供一个出色的学习环境。