Workshop: A Hands-On Summer School on Cell Mechanics for Engineers and Biologists; held Univ. of Illinois-Urbana; May 14-18, 2007

研讨会:为工程师和生物学家举办的细胞力学实践暑期学校;

基本信息

  • 批准号:
    0732253
  • 负责人:
  • 金额:
    $ 3.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-06-15 至 2008-05-31
  • 项目状态:
    已结题

项目摘要

There is increasing experimental evidence suggesting that extracellular and intracellular mechanical forces have a profound influence on a wide range of cell behavior such as growth, differentiation, and gene expression. The proposed summer course will highlight the current understanding on the processes by which cells transduce mechanical signals to functionality. Renowned experts in the field will deliver lectures in an instructional format (e.g., 1-hr lecture, 1-hr discussion) that cover both the basics and advanced knowledge. The lectures will be followed by hands-on lab experiments using nano scale devices that explore various aspects of cell mechano sensitivity. One highlight of the experiments will be to study cytoskeletal dynamics as cells grow on functionalized substrates with varying compliances. The workshop will offer a unique research and educational experience for the participants. They will be exposed to basics and advanced topics on cell and molecular biology, mechanics and thermodynamics, and molecular computations. Through the hands on experiments, participants will learn cell culture, advanced florescent microscopy including single molecule detection, application of nano scale sensors and devices and their fabrication. The participants from biological and physical sciences, and engineering will learn each others' trades and languages to foster further scientific interactions. The course materials, such as lecture notes and videos, laboratory hand-outs, video clips of key experimental steps, will be disseminated through the web. Hence, the summer school will have a long term impact on a broad audience from physical sciences and biology that are entering in the new interdisciplinary fields of research.
越来越多的实验证据表明,细胞外和细胞内的机械力对细胞的生长、分化和基因表达等广泛的行为具有深远的影响。拟议的夏季课程将突出当前对细胞将机械信号转换为功能的过程的理解。该领域的知名专家将以教学形式授课(例如,1小时讲课,1小时讨论),涵盖基础知识和高级知识。讲座之后,将使用纳米级设备进行动手实验室实验,探索细胞机械敏感性的各个方面。实验的一个亮点将是研究细胞在不同顺应性的功能化底物上生长时的细胞骨架动力学。工作坊将为与会者提供独特的研究和教育体验。他们将接触到细胞和分子生物学、力学和热力学以及分子计算的基础和高级主题。通过动手实验,参与者将学习细胞培养、包括单分子检测在内的先进荧光显微镜、纳米级传感器和设备的应用及其制造。来自生物和物理科学以及工程学的参与者将学习彼此的行业和语言,以促进进一步的科学互动。课程材料,如课堂讲稿和视频、实验讲义、关键实验步骤的视频剪辑等,将通过网络传播。因此,暑期班将对正在进入新的跨学科研究领域的物理科学和生物学的广大受众产生长期影响。

项目成果

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Taher Saif其他文献

Partial Treatment of <em>In Vivo</em> Single Axons by Mounting a Microfluidic Device Directly
  • DOI:
    10.1016/j.bpj.2017.11.3618
  • 发表时间:
    2018-02-02
  • 期刊:
  • 影响因子:
  • 作者:
    Anthony Fan;Alireza Tofangchi;Taher Saif
  • 通讯作者:
    Taher Saif
Enabling scalable parallel implementations of structured adaptive mesh refinement applications
  • DOI:
    10.1007/s11227-007-0110-z
  • 发表时间:
    2007-02-28
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Sumir Chandra;Xiaolin Li;Taher Saif;Manish Parashar
  • 通讯作者:
    Manish Parashar

Taher Saif的其他文献

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{{ truncateString('Taher Saif', 18)}}的其他基金

FORce-Mediated Cognition by Exercise (FORCE)
力介导的运动认知 (FORCE)
  • 批准号:
    2342257
  • 财政年份:
    2024
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
An ultra-sensitive micro sensor for biophysical studies of single cells cultured in 3D extracellular matrix
用于 3D 细胞外基质中培养的单细胞生物物理研究的超灵敏微传感器
  • 批准号:
    1934991
  • 财政年份:
    2019
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Force Pathway to Synaptic Vesicle Clustering in Embryonic Fruit Fly Neuro Muscular Junctions
胚胎果蝇神经肌肉接头突触小泡聚集的力通路
  • 批准号:
    1935181
  • 财政年份:
    2019
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
EAGER: Exploring Cell-Cell Gap as a Critical Parameter in Biological Phase Changes
EAGER:探索细胞间间隙作为生物相变的关键参数
  • 批准号:
    1742908
  • 财政年份:
    2017
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Effect Of Small Size, Stress Localization And Stress Gradient On The Strength Of Silicon
小尺寸、应力局部化和应力梯度对硅强度的影响
  • 批准号:
    1562694
  • 财政年份:
    2016
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Cell and Matrix Mechanobiology: Current State and Future Directions; University of Illinois at Urbana-Champaign; October 26-28, 2015
细胞和基质力学生物学:现状和未来方向;
  • 批准号:
    1546976
  • 财政年份:
    2015
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Exploring the Impact of Mechanical Force on Synaptic Functions Using Novel Approaches
使用新方法探索机械力对突触功能的影响
  • 批准号:
    1300808
  • 财政年份:
    2013
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Exploring Size Dependent Brittle-to-Ductile Transition in Single Crystal Silicon Using High Temperature MEMS
使用高温 MEMS 探索单晶硅中与尺寸相关的脆性到延性转变
  • 批准号:
    1102201
  • 财政年份:
    2011
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Regulation of Cancer Cell Metastasis by Mechanical Force
机械力调节癌细胞转移
  • 批准号:
    1002165
  • 财政年份:
    2010
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant
Understanding Force-Induced Learning and Memory
了解力诱导的学习和记忆
  • 批准号:
    0800870
  • 财政年份:
    2008
  • 资助金额:
    $ 3.07万
  • 项目类别:
    Standard Grant

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