Cell and Matrix Mechanobiology: Current State and Future Directions; University of Illinois at Urbana-Champaign; October 26-28, 2015
细胞和基质力学生物学:现状和未来方向;
基本信息
- 批准号:1546976
- 负责人:
- 金额:$ 4.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2017-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goals of the workshop, Cell and Matrix Mechanobiology: Current State and Future Directions; University of Illinois at Urbana-Champaign; October 26-28, 2015; are to (1) clearly define the important barriers to progress in understanding how living cells feel and change their mechanical environment, (2) to discuss and define possible experiments and computer programs that are the tools needed to understand how mechanical sensation creates changes in cell activity, migration and tissue growth, (3) to explore the potential societal impact from developing new engineering technologies that artificially mimic the ability of cells to sense mechanical loading and adapt material microstructure, and, finally, (4) to create a research roadmap to guide the field so that the important goals can be achieved.Considerable experimental evidence acquired during the last three decades has now established that extracellular biophysical cues, such as forces and matrix stiffness, have a profound influence on a wide range of cell behaviors such as growth, motility, differentiation, apoptosis, gene expression, adhesion and signal transduction. More recently, it has been appreciated that cells not only respond to these cues from the matrix, but also remodel the matrix and hence influence the subsequent cues. This dynamic reciprocity gives rise to emergent properties of the cell/matrix system, and both components co-evolve with time. This is particularly prevalent in embryogenesis, development and tumor growth. The precise role of mechanics in determining this reciprocity remains elusive. World experts in the field attending the workshop will develop a roadmap and white paper for members of the community and the National Science Foundation to help guide future research to maximize the effectiveness of investigations in the new and potentially highly important research field.
研讨会的目标,细胞和基质力学生物学:现状和未来方向;伊利诺伊大学厄巴纳-香槟分校;2015年10月26-28日;(1)明确定义在理解活细胞如何感受和改变其机械环境方面取得进展的重要障碍;(2)讨论和定义可能的实验和计算机程序,这些实验和计算机程序是理解机械感觉如何在细胞活动、迁移和组织生长中产生变化所需的工具;(3)探索人工模拟细胞感知机械载荷和适应材料微观结构能力的新工程技术的潜在社会影响;最后,(4)创建一个研究路线图来指导该领域,以便实现重要目标。在过去三十年中获得的大量实验证据已经确定,细胞外生物物理信号,如力和基质刚度,对细胞的生长、运动、分化、凋亡、基因表达、粘附和信号转导等广泛的细胞行为有深远的影响。最近,人们认识到细胞不仅对来自基质的这些提示作出反应,而且还重塑基质,从而影响随后的提示。这种动态的相互作用产生了细胞/基质系统的涌现特性,这两个组成部分随着时间的推移共同进化。这在胚胎发生、发育和肿瘤生长中尤为普遍。力学在决定这种相互作用中的确切作用仍然难以捉摸。参加研讨会的该领域的世界专家将为社区成员和国家科学基金会制定路线图和白皮书,以帮助指导未来的研究,以最大限度地提高新的和潜在的高度重要的研究领域的调查效率。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Taher Saif其他文献
Partial Treatment of <em>In Vivo</em> Single Axons by Mounting a Microfluidic Device Directly
- DOI:
10.1016/j.bpj.2017.11.3618 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Anthony Fan;Alireza Tofangchi;Taher Saif - 通讯作者:
Taher Saif
Enabling scalable parallel implementations of structured adaptive mesh refinement applications
- DOI:
10.1007/s11227-007-0110-z - 发表时间:
2007-02-28 - 期刊:
- 影响因子:2.700
- 作者:
Sumir Chandra;Xiaolin Li;Taher Saif;Manish Parashar - 通讯作者:
Manish Parashar
Taher Saif的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Taher Saif', 18)}}的其他基金
FORce-Mediated Cognition by Exercise (FORCE)
力介导的运动认知 (FORCE)
- 批准号:
2342257 - 财政年份:2024
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
An ultra-sensitive micro sensor for biophysical studies of single cells cultured in 3D extracellular matrix
用于 3D 细胞外基质中培养的单细胞生物物理研究的超灵敏微传感器
- 批准号:
1934991 - 财政年份:2019
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Force Pathway to Synaptic Vesicle Clustering in Embryonic Fruit Fly Neuro Muscular Junctions
胚胎果蝇神经肌肉接头突触小泡聚集的力通路
- 批准号:
1935181 - 财政年份:2019
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
EAGER: Exploring Cell-Cell Gap as a Critical Parameter in Biological Phase Changes
EAGER:探索细胞间间隙作为生物相变的关键参数
- 批准号:
1742908 - 财政年份:2017
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Effect Of Small Size, Stress Localization And Stress Gradient On The Strength Of Silicon
小尺寸、应力局部化和应力梯度对硅强度的影响
- 批准号:
1562694 - 财政年份:2016
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Exploring the Impact of Mechanical Force on Synaptic Functions Using Novel Approaches
使用新方法探索机械力对突触功能的影响
- 批准号:
1300808 - 财政年份:2013
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Exploring Size Dependent Brittle-to-Ductile Transition in Single Crystal Silicon Using High Temperature MEMS
使用高温 MEMS 探索单晶硅中与尺寸相关的脆性到延性转变
- 批准号:
1102201 - 财政年份:2011
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Regulation of Cancer Cell Metastasis by Mechanical Force
机械力调节癌细胞转移
- 批准号:
1002165 - 财政年份:2010
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Understanding Force-Induced Learning and Memory
了解力诱导的学习和记忆
- 批准号:
0800870 - 财政年份:2008
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Towards a neuro-mechanical memory element
走向神经机械记忆元件
- 批准号:
0801928 - 财政年份:2008
- 资助金额:
$ 4.92万 - 项目类别:
Continuing Grant
相似国自然基金
基于Matrix2000加速器的个性小数据在线挖掘
- 批准号:2020JJ4669
- 批准年份:2020
- 资助金额:0.0 万元
- 项目类别:省市级项目
多模强激光场R-MATRIX-FLOQUET理论
- 批准号:19574020
- 批准年份:1995
- 资助金额:7.5 万元
- 项目类别:面上项目
相似海外基金
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
用于血管平滑肌细胞力学生物学和病理学的仿生血管基质
- 批准号:
10586599 - 财政年份:2023
- 资助金额:
$ 4.92万 - 项目类别:
Microfabricated bioactive hydrogel platform as in vitro models to understand the mechanobiology of cell-matrix interaction in human tissue
微制造的生物活性水凝胶平台作为体外模型来了解人体组织中细胞-基质相互作用的力学生物学
- 批准号:
RGPIN-2021-03200 - 财政年份:2022
- 资助金额:
$ 4.92万 - 项目类别:
Discovery Grants Program - Individual
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
用于血管平滑肌细胞力学生物学和病理学的仿生血管基质
- 批准号:
10683796 - 财政年份:2022
- 资助金额:
$ 4.92万 - 项目类别:
CAREER: Elucidating the Role of Collective Cell-Matrix Interactions in the Mechanobiology of Airway Narrowing
职业:阐明集体细胞-基质相互作用在气道狭窄的力学生物学中的作用
- 批准号:
2047207 - 财政年份:2021
- 资助金额:
$ 4.92万 - 项目类别:
Standard Grant
Single-cell mechanobiology: microengineered tools to study cell-matrix remodelling
单细胞力学生物学:研究细胞基质重塑的微工程工具
- 批准号:
RGPIN-2015-05512 - 财政年份:2021
- 资助金额:
$ 4.92万 - 项目类别:
Discovery Grants Program - Individual
Microfabricated bioactive hydrogel platform as in vitro models to understand the mechanobiology of cell-matrix interaction in human tissue
微制造的生物活性水凝胶平台作为体外模型来了解人体组织中细胞-基质相互作用的力学生物学
- 批准号:
RGPIN-2021-03200 - 财政年份:2021
- 资助金额:
$ 4.92万 - 项目类别:
Discovery Grants Program - Individual
Nanopatterning of advanced research tools to harness the mechanobiology of cell-matrix interaction for stem cell expansion
先进研究工具的纳米图案利用细胞-基质相互作用的机械生物学来进行干细胞扩增
- 批准号:
RGPIN-2016-04043 - 财政年份:2020
- 资助金额:
$ 4.92万 - 项目类别:
Discovery Grants Program - Individual
Single-cell mechanobiology: microengineered tools to study cell-matrix remodelling
单细胞力学生物学:研究细胞基质重塑的微工程工具
- 批准号:
RGPIN-2015-05512 - 财政年份:2020
- 资助金额:
$ 4.92万 - 项目类别:
Discovery Grants Program - Individual
Mechanobiology of epithelial cell-matrix interaction
上皮细胞-基质相互作用的力学生物学
- 批准号:
539573-2019 - 财政年份:2019
- 资助金额:
$ 4.92万 - 项目类别:
University Undergraduate Student Research Awards
Volumetric time-lapse imaging of biophysical cell-extracellular matrix interactions for systems mechanobiology research
用于系统力学生物学研究的生物物理细胞-细胞外基质相互作用的体积延时成像
- 批准号:
10165754 - 财政年份:2019
- 资助金额:
$ 4.92万 - 项目类别: