EMSW21-RTG: Complex Biological Systems Across Multiple Space and Time Scales

EMSW21-RTG：跨多个空间和时间尺度的复杂生物系统

• 批准号: 0739261
• 负责人: Jonathan Rubin
• 金额: $ 186.39万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0739261&HistoricalAwards=false
• 关键词: EMSW21; RTG; Complex; Biological; Systems

This Research Training Group (RTG) will focus on training a new generation of scientists in (i) the development of analytical and computational algorithms for solving complex spatio-temporal problems that arise in biology and (ii) applications of these and other methods to problems arising in neuroscience and inflammation. In particular, on the computational side, this project will develop effective discretizations of coupled biological processes, iterative solvers and coupling/decoupling strategies. Within the neuroscience application, the investigators will derive new results on propagating waves and sustained activity patterns, synchrony and rhythmicity, noise and synaptic plasticity. Within the inflammation application, the research projects deal with the immune response to influenza infection, inflammation and sepsis, and models of necrotizing enterocolitis and wound healing.This project builds on the research and training experience of the principal investigators who have ongoing successful collaborations with the departments of Neuroscience and of Computational Biology, the Center for Inflammation and Regeneration Modeling and the Center for the Neural Basis of Cognition. The trainees are postdoctoral fellows and graduate and undergraduate students. They will participate in a variety of integrated research and training activities, including regular trainee presentations, journal clubs, working groups and research seminars, semiannual RTG Theme Days, an annual retreat, and an online forum. The biomedical applications targeted in this project are of enormous importance to society, as symbolized by the inclusion of inflammation as an NIH roadmap emphasis area for 2008 and the NIH Blueprint for Neuroscience Research.

该研究培训小组（RTG）将专注于培训新一代科学家（i）开发分析和计算算法，以解决生物学中出现的复杂时空问题，以及（ii）将这些方法和其他方法应用于神经科学和炎症中出现的问题。特别是在计算方面，该项目将开发耦合生物过程，迭代求解器和耦合/解耦策略的有效离散化。 在神经科学应用中，研究人员将获得关于传播波和持续活动模式、同步性和节律性、噪声和突触可塑性的新结果。 在炎症应用中，研究项目涉及流感感染的免疫反应，炎症和败血症，以及坏死性小肠结肠炎和伤口愈合的模型。该项目建立在主要研究者的研究和培训经验的基础上，他们与神经科学和计算生物学部门进行了成功的合作，炎症和再生建模中心和认知神经基础中心。受训人员为博士后研究员、研究生和本科生。他们将参加各种综合研究和培训活动，包括定期学员演讲，期刊俱乐部，工作组和研究研讨会，半年度RTG主题日，年度务虚会和在线论坛。该项目所针对的生物医学应用对社会具有巨大的重要性，这体现在将炎症纳入NIH 2008年路线图重点领域和NIH神经科学研究蓝图中。