Towards a neuro-mechanical memory element
走向神经机械记忆元件
基本信息
- 批准号:0801928
- 负责人:
- 金额:$ 33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-05-01 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Towards a neuro-mechanical memory elementAbstractThe objective of this project is to explore whether a neuro-mechanical synapse can be formed by interfacing a neuron cell with a silicon substrate. It is based on our recent finding that mechanical force applied at a neuromuscular synapse of Drosophila (fruit fly) embryos produces neuronal memory. This mechano-sensing ability of neurons is likely rooted in evolutionarily conserved properties of cells. It has thus the potential to apply to neuro-silico interfaces. The approach to this goal are: (1) investigate whether mechanically applied tension on a neuron using a silicon probe can be transduced into information that can be captured, e.g., as an image; (2) functionalize the probe to explore whether synapse can be engineered, and (3) explore whether engineered synapse can attain usage dependent force sensitive memory. Intellectual merit: The study will shed light, for the first time, on whether (and how) nature employs mechanical tension to store and process information in an analogue fashion. It then attempts to translate the knowledge to engineer a neuro-mechanical synapse. If this possibility is realized, it will be a breakthrough in the engineering of learning and memory into synthetic systems.Broader impact: This study will lay the foundation for creating networks of synthetic cells that could learn and remember patterns and share that knowledge with devices and sensors. The knowledge will be integrated with education through (1) development of a new course on neuro-mechanics (2) student seminars, (3) hands on teaching modules at the local Children?s Science Museum, and (4) web page development.
走向神经机械记忆元件这个项目的目标是探索能否通过将神经元细胞与硅衬底相连接来形成神经机械突触。这是基于我们最近的发现,施加在果蝇(果蝇)胚胎的神经肌肉突触上的机械力可以产生神经记忆。神经元的这种机械感知能力可能植根于细胞在进化上保守的特性。因此,它有可能应用于神经-硅胶接口。实现这一目标的方法是:(1)研究使用硅探针对神经元施加的机械张力是否可以转换为可以捕获的信息,例如,作为图像;(2)使探针功能化,以探索突触是否可以被工程化;以及(3)探索工程突触是否可以获得使用依赖力敏感记忆。智力优势:这项研究将首次揭示自然界是否(以及如何)使用机械张力以模拟的方式存储和处理信息。然后,它试图将这些知识转化为神经机械突触。如果这一可能性成为现实,这将是将学习和记忆工程转化为合成系统的一个突破。广泛的影响:这项研究将为创建能够学习和记忆模式并与设备和传感器共享知识的合成细胞网络奠定基础。这些知识将通过(1)开发一门新的神经力学课程(2)学生研讨会,(3)在当地的S儿童科学馆实践教学模块,以及(4)网页开发,将这些知识与教育相结合。
项目成果
期刊论文数量(0)
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Taher Saif其他文献
Partial Treatment of <em>In Vivo</em> Single Axons by Mounting a Microfluidic Device Directly
- DOI:
10.1016/j.bpj.2017.11.3618 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Anthony Fan;Alireza Tofangchi;Taher Saif - 通讯作者:
Taher Saif
Enabling scalable parallel implementations of structured adaptive mesh refinement applications
- DOI:
10.1007/s11227-007-0110-z - 发表时间:
2007-02-28 - 期刊:
- 影响因子:2.700
- 作者:
Sumir Chandra;Xiaolin Li;Taher Saif;Manish Parashar - 通讯作者:
Manish Parashar
Taher Saif的其他文献
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{{ truncateString('Taher Saif', 18)}}的其他基金
FORce-Mediated Cognition by Exercise (FORCE)
力介导的运动认知 (FORCE)
- 批准号:
2342257 - 财政年份:2024
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
An ultra-sensitive micro sensor for biophysical studies of single cells cultured in 3D extracellular matrix
用于 3D 细胞外基质中培养的单细胞生物物理研究的超灵敏微传感器
- 批准号:
1934991 - 财政年份:2019
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Force Pathway to Synaptic Vesicle Clustering in Embryonic Fruit Fly Neuro Muscular Junctions
胚胎果蝇神经肌肉接头突触小泡聚集的力通路
- 批准号:
1935181 - 财政年份:2019
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
EAGER: Exploring Cell-Cell Gap as a Critical Parameter in Biological Phase Changes
EAGER:探索细胞间间隙作为生物相变的关键参数
- 批准号:
1742908 - 财政年份:2017
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Effect Of Small Size, Stress Localization And Stress Gradient On The Strength Of Silicon
小尺寸、应力局部化和应力梯度对硅强度的影响
- 批准号:
1562694 - 财政年份:2016
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Cell and Matrix Mechanobiology: Current State and Future Directions; University of Illinois at Urbana-Champaign; October 26-28, 2015
细胞和基质力学生物学:现状和未来方向;
- 批准号:
1546976 - 财政年份:2015
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Exploring the Impact of Mechanical Force on Synaptic Functions Using Novel Approaches
使用新方法探索机械力对突触功能的影响
- 批准号:
1300808 - 财政年份:2013
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Exploring Size Dependent Brittle-to-Ductile Transition in Single Crystal Silicon Using High Temperature MEMS
使用高温 MEMS 探索单晶硅中与尺寸相关的脆性到延性转变
- 批准号:
1102201 - 财政年份:2011
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Regulation of Cancer Cell Metastasis by Mechanical Force
机械力调节癌细胞转移
- 批准号:
1002165 - 财政年份:2010
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Understanding Force-Induced Learning and Memory
了解力诱导的学习和记忆
- 批准号:
0800870 - 财政年份:2008
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
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