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DISSERTATION RESEARCH: Is bacterial persistence an altruistic, selfish, or kin-selected social trait?

论文研究：细菌的持久性是一种利他、自私或亲属选择的社会特征吗？

基本信息

批准号：
0808234
负责人：
Robert Ford Denison
金额：
$ 1.05万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-15 至 2010-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808234&HistoricalAwards=false
关键词：
DISSERTATION RESEARCH bacterial persistence altruistic

项目摘要

Bacteria that become "persisters" can survive stress (such as starvation or application of antibiotics), but cannot reproduce. Persisters consume less food, making more food available for other bacteria. Did the persistence trait evolve because it helps individuals to survive stress, or because it is advantageous to bacterial groups, especially close relatives? Computer models and experiments with different mixtures of harmless bacteria under different conditions will be used to investigate this issue. Bacteria that fluoresce different colors will be used, so that they can be distinguished for measurements.Diseases caused by persister bacteria are more difficult to cure because they are hard to kill, even with antibiotics that kill active individuals of the same strains. This research may suggest how hospital conditions and treatments affect the rapid evolution of bacterial persistence, even within a single patient. In addition, if persistence is in fact an example of individuals sacrificing their own success for the common good of their relatives, then this system can be used to study the evolution of cooperation, doing experiments in days that would take decades with multicellular organisms. This research will provide training opportunities for high school and undergraduate students.

成为“坚持者”的细菌可以在压力下生存（如饥饿或抗生素的应用），但不能繁殖。坚持者消耗更少的食物，为其他细菌提供更多的食物。持久性特征的进化是因为它有助于个体在压力下生存，还是因为它对细菌群体，特别是近亲有利？计算机模型和不同条件下的无害细菌的不同混合物的实验将被用来调查这个问题。使用荧光颜色不同的细菌，以便在测量中区分它们。由持续存在的细菌引起的疾病更难治愈，因为它们很难杀死，即使使用抗生素杀死相同菌株的活性个体也是如此。这项研究可能表明医院条件和治疗如何影响细菌持久性的快速演变，即使在单个患者中也是如此。此外，如果坚持实际上是个体为了亲属的共同利益而牺牲自己的成功的一个例子，那么这个系统可以用来研究合作的进化，在几天内完成多细胞生物需要几十年的实验。这项研究将为高中生和本科生提供培训机会。