DISSERTATION RESEARCH: Is bacterial persistence an altruistic, selfish, or kin-selected social trait?

论文研究：细菌的持久性是一种利他、自私或亲属选择的社会特征吗？

• 批准号: 0808234
• 负责人: Robert Ford Denison
• 金额: $ 1.05万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808234&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; bacterial; persistence; altruistic

Bacteria that become "persisters" can survive stress (such as starvation or application of antibiotics), but cannot reproduce. Persisters consume less food, making more food available for other bacteria. Did the persistence trait evolve because it helps individuals to survive stress, or because it is advantageous to bacterial groups, especially close relatives? Computer models and experiments with different mixtures of harmless bacteria under different conditions will be used to investigate this issue. Bacteria that fluoresce different colors will be used, so that they can be distinguished for measurements.Diseases caused by persister bacteria are more difficult to cure because they are hard to kill, even with antibiotics that kill active individuals of the same strains. This research may suggest how hospital conditions and treatments affect the rapid evolution of bacterial persistence, even within a single patient. In addition, if persistence is in fact an example of individuals sacrificing their own success for the common good of their relatives, then this system can be used to study the evolution of cooperation, doing experiments in days that would take decades with multicellular organisms. This research will provide training opportunities for high school and undergraduate students.

成为“持久”的细菌可以在压力（例如饥饿或抗生素的应用）中生存，但不能繁殖。 持久食品消耗少食物，使其他细菌的食物更多。 持久性状是否发展是因为它可以帮助个人生存压力，或者是因为它对细菌群体，尤其是近亲有利？ 在不同条件下使用不同混合物混合物的计算机模型和实验将用于研究此问题。 将使用荧光的细菌，以便将它们区分开以进行测量。持久细菌引起的疾病更难固化，因为它们很难杀死，即使杀死了相同菌株的活跃个体的抗生素。 这项研究可能表明，即使在单个患者中，医院的状况和治疗也如何影响细菌持久性的快速演变。 此外，如果持久性实际上是个人为亲戚的共同利益而牺牲自己的成功的一个例子，那么该系统可以用来研究合作的演变，在几天内进行数十年的多细胞生物进行实验。这项研究将为高中和本科生提供培训机会。