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CPA-DA: Hierarchical Design Tools for Bio-NEMS

CPA-DA: Hierarchical Design Tools for Bio-NEMS
CPA-DA:Bio-NEMS 的分层设计工具
批准号:
0810294
负责人:
Narayana Aluru
金额:
$30.0万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-08-15 至 2012-07-31

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中文摘要
翻译
提案编号:0810294标题:CPA-DA:Bio-NEMS的分层设计工具主要研究者:N。R. Aluru机构:摘要聚合物是纳米机电(NEMS)的理想材料,因为它们可以响应各种刺激,如pH值,盐浓度,电场等。聚合物具有易于制造,廉价,一次性,生物相容性,低功耗致动器,并表现出有吸引力的灵敏度和选择性特性。基于聚合物的NEMS可应用于传感细胞、蛋白质、DNA和生物分子,并作为微流体网络的关键组件,应用于化学和生物分析。基于聚合物的生物NEMS设备与微流体、MEMS和控制电子设备相结合,可以在集成系统的设计和开发方面取得重大进展。本提案的目的是开发分层设计工具,以实现快速设计和开发的生物NEMS。拟议的研究重点是进行量子力学研究以了解聚合物的静电行为,原子模拟以了解聚合物中的扩散并提取表征生物材料本构行为的应力-应变关系,基于耦合化学,电学和力学理论的连续计算以了解宏观响应,并从详细和广泛的连续模拟中提取生物NEMS设备的紧凑模型。这里提出的研究是多学科的,可以从这项研究中受益的一些应用是纳米级传感和驱动,DNA纯化,化学和生物处理等,该项目将导致在生物NEMS的高度跨学科领域的研究生教育。从事该项目的学生将接受量子,原子和连续模拟方法,聚合物物理,系统级建模和大规模集成生物NEMS系统设计的培训。该项目的成果将在世界各地的档案期刊和会议上发表。此外,该项目的成果将被整合到现有的MEMS建模和仿真课程以及UIUC提供的暑期学校中。
英文摘要
Proposal Number: 0810294Title: CPA-DA: Hierarchical Design Tools for Bio-NEMSPrincipal Investigator: N. R. Aluru Institution: University of Illinois at Urbana-ChampaignAbstractPolymers are attractive materials for nanoelectromechanical (NEMS) as they can respond to various stimuli such as pH, salt concentration, electric field, etc. Polymers are easy to manufacture, cheap, disposable, biocompatible, low-power actuators and exhibit attractive sensitivity and selectivity properties. Polymer-based NEMS find applications in sensing cells, proteins, DNA and biomolecules, and as key components in microfluidic networks with applications in chemical and biological analysis. Polymer-based bio-NEMS devices when combined with microfluidics, MEMS, and control electronics can enable significant advances in the design and development of integrated systems. The objective of this proposal is to develop hierarchical design tools to enable rapid design and development of bio-NEMS. The proposed research focuses on performing quantum-mechanical studies to understand the electrostatic behavior of polymers, atomistic simulations to understand diffusion in polymers and to extract stress-strain relations characterizing the constitutive behavior of the biomaterials, continuum calculations based on coupled chemical, electrical, and mechanical theories to understand the macroscopic response, and extracting compact models for bio-NEMS devices from detailed and extensive continuum simulations. The research proposed here is multidisciplinary and some of the applications that could benefit from this research are nanoscale sensing and actuation, DNA purification, chemical and biological processing, etc. This project will result in the education of graduate students in the highly interdisciplinary area of bio-NEMS. Students working on this project will be trained in quantum, atomistic and continuum simulation methods, physics of polymers, system-level modeling and design of large scale integrated bio-NEMS systems. The results from this project will be presented in archival journals and conferences around the world. In addition, the results from this project will be integrated into an existing course on modeling and simulation of MEMS and summer schools offered at UIUC.
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