The Plant Epigenome - Frontiers in Gene Regulation

植物表观基因组 - 基因调控前沿

• 批准号: 0823364
• 负责人: Robert Martienssen
• 金额: $ 3万
• 依托单位: Cold Spring Harbor Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2009-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0823364&HistoricalAwards=false
• 关键词: Plant; Epigenome; Frontiers; Gene; Regulation

Epigenetics (inherited changes in phenotype not due to changes in DNA sequence) is a critical mode of gene control recently realized to have far reaching effects. It is caused by modification of the chromatin (DNA plus associated proteins) and acts at a level above normal gene control. How changes in chromatin cause changes in gene expression is a major area of research activity in both animals and plants. Understanding epigenetic control of genes will elucidate gene control of development, response to climatic stresses such as drought and heat and interaction with disease causing organisms. Several plant genomes have now been sequenced so it is feasible to examine the epigenetic changes occurring during development or in response to the environment in these organisms. The goal is to determine, as part of an international collaboration, the epigenetic marks on chromatin at particular genes in different tissues, at different stages of development and in response to biotic and abiotic challenges and to see how they differ, potentially leading to ways of manipulating the expression of these genes. This workshop, to be jointly sponsored by NSF and science funding agencies in the UK and Australia, will bring together approximately 40 scientists, both leading experts and early career, to participate in a forum for discussion of cutting edge research in this area and the setting up of an international Plant Epigenome Consortium. The 'state-of-play' internationally will be reviewed and then the 'nuts and bolts' of setting up a collaboration will be worked out. In addition, early career stage invitees will have the opportunity to visit nniversities and institutes in Australia after the meeting to further these international collaborative goals.

表观遗传学（表型的遗传变化，而不是由于DNA序列的变化）是一种重要的基因控制模式，最近意识到具有深远的影响。它是由染色质（DNA加上相关蛋白质）的修饰引起的，并在高于正常基因控制的水平上起作用。染色质的变化如何引起基因表达的变化是动物和植物研究活动的一个主要领域。了解基因的表观遗传控制将阐明基因控制的发展，应对气候压力，如干旱和炎热，并与疾病引起的生物体的相互作用。几种植物的基因组已经被测序，因此研究这些生物在发育过程中或对环境的反应中发生的表观遗传变化是可行的。作为国际合作的一部分，目标是确定不同组织中特定基因的染色质上的表观遗传标记，在不同的发育阶段以及应对生物和非生物挑战，并了解它们如何不同，可能导致操纵这些基因表达的方法。该研讨会将由NSF和英国和澳大利亚的科学资助机构联合赞助，将汇集大约40名科学家，包括领先的专家和早期职业，参加一个论坛，讨论该领域的前沿研究和建立国际植物表观基因组联盟。将审查国际上的“现状”，然后制定建立合作的“螺母和螺栓”。此外，早期职业阶段的受邀者将有机会在会后访问澳大利亚的大学和研究所，以进一步实现这些国际合作目标。