WINeRS: A Multichannel Wireless Implantable Neural Recording and Stimulating System for Hippocampal Electrophysiology Research on Memory

目的：本研究的目的是开发一种多通道无线植入式神经记录和刺激(WINERS)系统，用于神经生物学研究中与中枢神经系统的双向接口。该系统将在海马区关于记忆的电生理学研究的背景下进行评估。智能优点：高功率、大尺寸、低效率、有限带宽以及对噪声和干扰的敏感性是此类系统开发中的一些主要现有挑战，这些挑战将通过采用模块化可扩展的片上系统架构来实现。超低噪声记录单元将是无时钟的，并可调节到神经信号中感兴趣的频段。它将具有抑制刺激伪影的能力和对带宽和活动通道数量的自适应分辨率。三个单独的射频载波将进行优化，以实现高效感应供电、高速率前向数据传输和跨皮肤的宽带反向遥测。将设计最先进的微组装，将多通道刺激和记录单元与多个天线、微线束和微机械电极阵列结合在一个头戴式封装上。更广泛的影响：针对海马体的疾病，如痴呆症和阿尔茨海默病？S在2007年影响了510万美国人，在老龄化的工业社会中正在迅速增长。拟议的微系统在神经科学家手中可能是无价的工具。拟议的努力还包括为本科生开发高级设计课程，并让本科生参与研究活动。

Objective:The objective of this research is to develop a multichannel Wireless Implantable Neural Recording and Stimulating (WINeRS) system to be used as a bidirectional interface with the central nervous system for neurobiology research applications. The system will be evaluated in the context of hippocampal electrophysiology research on memory. Intellectual Merit:High power, large size, low efficiency, limited bandwidth, and susceptibility to noise and interference are some of the major existing challenges in development of such systems, which will be targeted by adopting a modular scalable system-on-a-chip architecture. The ultra low-noise recording unit will be clockless and tunable to the frequency band of interest within the neural signal. It will have stimulus artifact rejection capability and adaptive resolution to the bandwidth and number of active channels. Three individual radio-frequency carriers will be optimized for high-efficiency inductive powering, high-rate forward data transmission, and wideband back telemetry across the skin. State-of-the-art microassembly will be devised to combine the multichannel stimulation and recording units with multiple antennas, microwire bundles, and micromachined electrode arrays on a head-mounted package. Broader Impact:Diseases that target the hippocampus, such as dementia and the Alzheimer?s, which affected 5.1 million Americans in 2007, are rapidly growing in the aging industrial societies. The proposed microsystem could be invaluable tool in the hands of neuroscientists. The proposed effort also includes the development of senior design courses for undergraduate students, and involved undergraduate students in research activities.