The Physiological Basis of Natural Variation in Germination Responses of Arabidopsis Thaliana

拟南芥萌发反应自然变异的生理基础

基本信息

  • 批准号:
    0844280
  • 负责人:
  • 金额:
    $ 34.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-07-01 至 2012-03-31
  • 项目状态:
    已结题

项目摘要

The physiological basis of natural variation in germination responses of Arabidopsis thalianaIn the life cycle of Arabidopsis thaliana and many other species, two developmental switches determine overall life history and consequent population biology: the switch to germination and the switch to flowering. Much is known about genes associated with adaptation in flowering time, molecular genetic pathways of flowering, and geographic distribution of natural variation in flowering time. Comparable effort devoted to understanding germination timing has the potential to provide significant insight into adaptation of entire life history schedules and the genetic basis of population variation. This research therefore focuses on the genetic basis and evolutionary ecology of germination timing. It has recently been found that the gene family of photoreceptors, the phytochromes, have important functions during germination that may give them the ability to regulate the season of germination. New data indicate that phytochromes are involved in both germination and its opposite trait: dormancy. Moreover, contributions of different phytochromes to germination depend on temperature. This research will test whether phytochrome can regulate the temperature of germination through mutant studies, compare gene expression in different phytochrome mutants, and test whether natural variation in germination involves variation in the expression of these same pathways. A geographic analysis of natural variation in germination responses will test for evidence of natural selection on germination on a regional scale. In addition to testing fundamental mechanisms of phytochrome regulation of germination, the proposed research will test for natural variation in the germination pathways regulated by phytochromes and test whether that natural variation is due to variation in expression of phytochrome-regulated genes or due to variation in phytochrome sequence itself. These studies of the genetic basis of germination responses and the geographic distribution of variation in germination will contribute significantly to our understanding of processes of range expansion and distributional changes accompanying environmental change. By combining modeling of flowering time and germination phenology, the goal is to predict life history and demography as a function of changing environmental conditions. Results of the phenotypic survey and microarray studies will be made available to the community and provide a foundation for future studies of the genetic basis of natural variation in germination. This research also supports international collaboration and training at various levels in genomic, physiological, and computational techniques.
拟南芥萌发反应自然变异的生理基础在拟南芥和许多其他物种的生命周期中,两个发育开关决定了整个生活史和随后的种群生物学:转向萌发和转向开花。人们对与花期适应相关的基因、开花的分子遗传途径以及花期自然变异的地理分布知道得很多。致力于了解萌发时间的类似努力有可能为整个生活史时间表的适应和种群变异的遗传基础提供重要的洞察力。因此,本研究侧重于种子萌发时机的遗传基础和进化生态学研究。最近发现,光感受器基因家族光敏色素在萌发过程中具有重要的功能,这可能使它们具有调节萌发季节的能力。新的数据表明,光敏色素参与了种子萌发及其相反的特性:休眠。此外,不同的光敏色素对萌发的贡献取决于温度。这项研究将通过突变研究来测试光敏色素是否可以调节发芽温度,比较不同光敏色素突变体的基因表达,并测试发芽的自然变异是否涉及这些相同途径的表达变化。对萌发反应的自然变异进行地理分析,将检验在区域范围内发芽是否存在自然选择的证据。除了测试光敏色素调节萌发的基本机制外,这项拟议的研究还将测试光敏色素调控的萌发途径中的自然变异,并测试这种自然变异是由于光敏色素调控基因表达的变化还是由于光敏色素序列本身的变化。这些对萌发反应的遗传基础和萌发变异的地理分布的研究将有助于我们理解伴随环境变化的范围扩大和分布变化的过程。通过结合开花时间和萌发物候的建模,目标是预测生活史和人口学作为环境条件变化的函数。表型调查和微阵列研究的结果将向社区提供,并为今后研究种子萌发自然变异的遗传基础奠定基础。这项研究还支持在基因组、生理和计算技术方面的不同水平的国际合作和培训。

项目成果

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Kathleen Donohue其他文献

Elevation filters seed traits and germination strategies in the eastern Tibetan Plateau
青藏高原东部海拔过滤种子性状及发芽策略
  • DOI:
    10.1111/ecog.04972
  • 发表时间:
    2020-11
  • 期刊:
  • 影响因子:
    5.9
  • 作者:
    Xuejing Wang;Mariano Alvarez;Kathleen Donohue;Wenjing Ge;Yueqian Cao;Kun Liu;Guozhen Du;Haiyan Bu
  • 通讯作者:
    Haiyan Bu
Cancer surveillance behaviors and psychosocial factors among long‐term survivors of breast cancer
乳腺癌长期幸存者的癌症监测行为和心理社会因素
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    6.2
  • 作者:
    M. Katz;Kathleen Donohue;C. Alfano;J. Day;J. Herndon;E. Paskett
  • 通讯作者:
    E. Paskett
LBP-044 Robust reduction of HBsAg and HDV RNA levels with low risk for ALT elevations in JNJ-73763989 treated patients with chronic hepatitis D (CHD) and baseline HBsAg levels below 10, 000 IU/ml: part 2 of the REEF-D study
  • DOI:
    10.1016/s0168-8278(24)00611-1
  • 发表时间:
    2024-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Heiner Wedemeyer;Pietro Lampertico;Edward J. Gane;Kosh Agarwal;Fehmi Tabak;Ulus Akarca;Soo Aleman;Maria Buti;Kathrin Sprinzl;Kathleen Donohue;John Jerzorwski;Thomas Kakuda;Thierry Verbinnen;Adam Bakala;Oliver Lenz;Michael Biermer
  • 通讯作者:
    Michael Biermer

Kathleen Donohue的其他文献

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{{ truncateString('Kathleen Donohue', 18)}}的其他基金

Collaborative Research: NSFGEO-NERC: QUICCHE: Quantifying Interocean fluxes in the Cape Cauldron Hotspot of Eddy kinetic energy
合作研究:NSFGEO-NERC:QUICCHE:量化涡流动能 Cape Cauldron 热点中的洋间通量
  • 批准号:
    2148677
  • 财政年份:
    2022
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Continuing Grant
BEE: Demographic and evolutionary consequences of phenological tracking
BEE:物候追踪的人口统计和进化后果
  • 批准号:
    2118654
  • 财政年份:
    2021
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Standard Grant
Collaborative Research: Eddy fluxes across the Southern Antarctic Circumpolar Current Front near Southeast Indian Ridge
合作研究:东南印度洋脊附近南极南部绕极流锋的涡流
  • 批准号:
    2023306
  • 财政年份:
    2020
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Continuing Grant
Epigenetic stability and its evolutionary potential
表观遗传稳定性及其进化潜力
  • 批准号:
    1556855
  • 财政年份:
    2016
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: The Phenotypic and Genetic Basis of Facilitation and Competition in Plants
论文研究:植物促进和竞争的表型和遗传基础
  • 批准号:
    1501710
  • 财政年份:
    2015
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Predicting Plant Life-Cycles in Changing Environments
论文研究:预测变化环境中的植物生命周期
  • 批准号:
    1311406
  • 财政年份:
    2013
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Standard Grant
Collaborative Research: Dynamics and Transport of the Antarctic Circumpolar Current in Drake Passage (cDrake) Analysis
合作研究:德雷克海峡南极绕极流的动力学和传输 (cDrake) 分析
  • 批准号:
    1141802
  • 财政年份:
    2012
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Standard Grant
REU Site: SURFO - Summer Undergraduate Research Fellowships in Oceanography
REU 网站:SURFO - 海洋学夏季本科生研究奖学金
  • 批准号:
    1156520
  • 财政年份:
    2012
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Continuing Grant
The genetic basis and adaptive significance of pleiotropy: FLC-regulated germination and flowering
多效性的遗传基础和适应性意义:FLC调控的发芽和开花
  • 批准号:
    1146383
  • 财政年份:
    2012
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: Divergent selection and the evolution of reproductive isolation across the genus Cakile (Brassicaceae)
论文研究:Cakile 属(十字花科)的发散选择和生殖隔离的进化
  • 批准号:
    1011329
  • 财政年份:
    2010
  • 资助金额:
    $ 34.56万
  • 项目类别:
    Standard Grant

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基于Volatility Basis-set方法对上海大气二次有机气溶胶生成的模拟
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  • 批准号:
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