The genetic basis and adaptive significance of pleiotropy: FLC-regulated germination and flowering
多效性的遗传基础和适应性意义:FLC调控的发芽和开花
基本信息
- 批准号:1146383
- 负责人:
- 金额:$ 108.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-01 至 2017-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
"Phenology", the timing of biological events such as germination and flowering, is one of the most important responses of plants to climate change, and it has been shown to influence performance and local extinctions. Different life stages must respond appropriately to seasonal environmental cues to match their development with the corresponding season. This project seeks to understand how the timing of two crucial phenological events, "germination and flowering" can adapt to seasonal variation even though they share a common genetic basis and must respond differently to similar seasonal environmental cues. Pleiotropy occurs when one gene controls more than one trait. Understanding how multiple traits can adapt when they are controlled by the same genes is a major challenge. Genes in a well known flowering pathway in Arabidopsis thaliana have recently been found to also regulate germination, thereby providing a powerful research system for investigating the genetic basis and adaptive significance of pleiotropy. The major regulator of flowering, FLOWERING LOCUS C (FLC), operates in a pathway that is one of the best characterized molecular pathways of an adaptively significant trait in plants, and it has become a classic system in ecological genetics. It was recently found that the immediate downstream elements in the FLC-flowering pathway also control the germination behavior of seeds, and that natural variation in FLC is associated with natural variation in temperature-dependent germination. This project aims to characterize pleiotropic effects of FLC and other elements in its pathway on both germination and flowering phenology, identify sources of natural variation in FLC-mediated pathways, and measure the fitness consequences of FLC (and FLC-pathway) variation operating through germination and flowering. This research explores the genetic basis of phenology and environmental cuing. As such, the project will provide basic information on how plants respond to environmental change. The project will also generate genomic data and genetic material that will be made available to the research community through The Arabidopsis Information Resource. This project will provide career opportunities and training in molecular genetics and ecological genetics to a postdoc, a graduate student, a research assistant, several undergraduates, and high school students. An educational module will be designed also so that students can explore how genetic pathways influence organismal responses to environmental change.
“物候”,即发芽和开花等生物事件的时间安排,是植物对气候变化最重要的反应之一,并且已被证明会影响性能和局部灭绝。 不同的生命阶段必须对季节环境因素做出适当的反应,使其发展与相应的季节相匹配。 该项目旨在了解两个关键物候事件“发芽和开花”的时间如何适应季节变化,尽管它们具有共同的遗传基础并且必须对相似的季节性环境线索做出不同的反应。当一个基因控制多个性状时,就会发生多效性。 了解多个性状在受相同基因控制时如何适应是一项重大挑战。 最近发现拟南芥中众所周知的开花途径中的基因也能调节发芽,从而为研究多效性的遗传基础和适应性意义提供了强大的研究系统。 开花的主要调节因子 FLOWERING LOCUS C (FLC) 的运作途径是植物适应性显着性状的最佳表征分子途径之一,并且它已成为生态遗传学中的经典系统。 最近发现,FLC 开花途径中的直接下游元件也控制种子的发芽行为,并且 FLC 的自然变化与温度依赖性发芽的自然变化相关。该项目旨在表征 FLC 及其途径中的其他元素对发芽和开花物候学的多效性影响,确定 FLC 介导途径中自然变异的来源,并测量 FLC(和 FLC 途径)变异通过发芽和开花产生的适应性后果。这项研究探讨了物候和环境提示的遗传基础。 因此,该项目将提供有关植物如何应对环境变化的基本信息。该项目还将生成基因组数据和遗传材料,通过拟南芥信息资源向研究界提供。 该项目将为一名博士后、一名研究生、一名研究助理、几名本科生和高中生提供分子遗传学和生态遗传学方面的就业机会和培训。 还将设计一个教育模块,以便学生能够探索遗传途径如何影响有机体对环境变化的反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kathleen Donohue其他文献
Elevation filters seed traits and germination strategies in the eastern Tibetan Plateau
青藏高原东部海拔过滤种子性状及发芽策略
- DOI:
10.1111/ecog.04972 - 发表时间:
2020-11 - 期刊:
- 影响因子:5.9
- 作者:
Xuejing Wang;Mariano Alvarez;Kathleen Donohue;Wenjing Ge;Yueqian Cao;Kun Liu;Guozhen Du;Haiyan Bu - 通讯作者:
Haiyan Bu
Cancer surveillance behaviors and psychosocial factors among long‐term survivors of breast cancer
乳腺癌长期幸存者的癌症监测行为和心理社会因素
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:6.2
- 作者:
M. Katz;Kathleen Donohue;C. Alfano;J. Day;J. Herndon;E. Paskett - 通讯作者:
E. Paskett
LBP-044 Robust reduction of HBsAg and HDV RNA levels with low risk for ALT elevations in JNJ-73763989 treated patients with chronic hepatitis D (CHD) and baseline HBsAg levels below 10, 000 IU/ml: part 2 of the REEF-D study
- DOI:
10.1016/s0168-8278(24)00611-1 - 发表时间:
2024-06-01 - 期刊:
- 影响因子:
- 作者:
Heiner Wedemeyer;Pietro Lampertico;Edward J. Gane;Kosh Agarwal;Fehmi Tabak;Ulus Akarca;Soo Aleman;Maria Buti;Kathrin Sprinzl;Kathleen Donohue;John Jerzorwski;Thomas Kakuda;Thierry Verbinnen;Adam Bakala;Oliver Lenz;Michael Biermer - 通讯作者:
Michael Biermer
Kathleen Donohue的其他文献
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{{ truncateString('Kathleen Donohue', 18)}}的其他基金
Collaborative Research: NSFGEO-NERC: QUICCHE: Quantifying Interocean fluxes in the Cape Cauldron Hotspot of Eddy kinetic energy
合作研究:NSFGEO-NERC:QUICCHE:量化涡流动能 Cape Cauldron 热点中的洋间通量
- 批准号:
2148677 - 财政年份:2022
- 资助金额:
$ 108.32万 - 项目类别:
Continuing Grant
BEE: Demographic and evolutionary consequences of phenological tracking
BEE:物候追踪的人口统计和进化后果
- 批准号:
2118654 - 财政年份:2021
- 资助金额:
$ 108.32万 - 项目类别:
Standard Grant
Collaborative Research: Eddy fluxes across the Southern Antarctic Circumpolar Current Front near Southeast Indian Ridge
合作研究:东南印度洋脊附近南极南部绕极流锋的涡流
- 批准号:
2023306 - 财政年份:2020
- 资助金额:
$ 108.32万 - 项目类别:
Continuing Grant
Epigenetic stability and its evolutionary potential
表观遗传稳定性及其进化潜力
- 批准号:
1556855 - 财政年份:2016
- 资助金额:
$ 108.32万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: The Phenotypic and Genetic Basis of Facilitation and Competition in Plants
论文研究:植物促进和竞争的表型和遗传基础
- 批准号:
1501710 - 财政年份:2015
- 资助金额:
$ 108.32万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Predicting Plant Life-Cycles in Changing Environments
论文研究:预测变化环境中的植物生命周期
- 批准号:
1311406 - 财政年份:2013
- 资助金额:
$ 108.32万 - 项目类别:
Standard Grant
Collaborative Research: Dynamics and Transport of the Antarctic Circumpolar Current in Drake Passage (cDrake) Analysis
合作研究:德雷克海峡南极绕极流的动力学和传输 (cDrake) 分析
- 批准号:
1141802 - 财政年份:2012
- 资助金额:
$ 108.32万 - 项目类别:
Standard Grant
REU Site: SURFO - Summer Undergraduate Research Fellowships in Oceanography
REU 网站:SURFO - 海洋学夏季本科生研究奖学金
- 批准号:
1156520 - 财政年份:2012
- 资助金额:
$ 108.32万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Divergent selection and the evolution of reproductive isolation across the genus Cakile (Brassicaceae)
论文研究:Cakile 属(十字花科)的发散选择和生殖隔离的进化
- 批准号:
1011329 - 财政年份:2010
- 资助金额:
$ 108.32万 - 项目类别:
Standard Grant
Collaborative research: Integrating genetically informed models of germination and flowering to predict life history responses to changing climate.
合作研究:整合发芽和开花的遗传信息模型来预测生命史对气候变化的反应。
- 批准号:
1020963 - 财政年份:2010
- 资助金额:
$ 108.32万 - 项目类别:
Continuing Grant
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