CAREER: Super-resolution in coherent anti-Stokes Raman scattering (CARS) microscopy

职业：相干反斯托克斯拉曼散射 (CARS) 显微镜的超分辨率

• 批准号: 0847097
• 负责人: Eric Potma
• 金额: $ 55万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847097&HistoricalAwards=false
• 关键词: CAREER; Super; resolution; coherent; anti

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). Eric Olaf Potma of the University of California, Irvine, is supported by an award from the Experimental Physical Chemistry program to develop a coherent anti-Stokes Raman scattering (CARS) microscope with super-resolution. Development of this microscope will enable chemically selective imaging with a resolution down to the 50 nm length scale, opening up new areas in optical imaging of biological samples and engineered materials. The instrument will be used to study the nonlinear optical response of metallic nanowires, and to examine the distribution of sub-micrometer sized lipids droplets in breast cancer cells. This work may lead to the development of methods that to better examine samples with microscopic and nanoscopic details. The investigator is also committed to utilize advanced instruments for the purpose of fostering enthusiasm for physical chemistry among high school students. An annual 4-week Summer School will be held, in which high school students have the opportunity to attend college-style lectures and participate in high-end research experiments.

该奖项根据 2009 年美国复苏和再投资法案（公法 111-5）提供资金。加州大学欧文分校的埃里克·奥拉夫·波特玛 (Eric Olaf Potma) 获得实验物理化学项目奖项的支持，开发出具有超分辨率的相干反斯托克斯拉曼散射 (CARS) 显微镜。这种显微镜的开发将使化学选择性成像的分辨率低至 50 nm 长度，开辟生物样品和工程材料光学成像的新领域。该仪器将用于研究金属纳米线的非线性光学响应，并检查乳腺癌细胞中亚微米大小的脂滴的分布。这项工作可能会导致更好地检查具有微观和纳米级细节的样品的方法的开发。研究者还致力于利用先进的仪器来培养高中生对物理化学的热情。每年举办为期4周的暑期学校，高中生有机会参加大学式的讲座并参与高端研究实验。