The Study of Ion/Ion Reactions at Atmospheric Pressure by Ambient Neutral Re-ionization Mass Spectrometry and Ambient Soft Landing

利用环境中性再电离质谱和环境软着陆研究大气压下离子/离子反应

• 批准号: 0911160
• 负责人: Hao Chen
• 金额: $ 31.43万
• 依托单位: Ohio University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911160&HistoricalAwards=false
• 关键词: Study; Ion; Reactions; Atmospheric; Pressure

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Analytical and Surface Chemistry Program supports Professor Hao Chen of Ohio University in studies targeting improved insight into the mechanisms of ion/ion reactions important for characterizing a wide range of molecules, including proteins. The approach entails structural analysis of neutral and ionic products of gaseous ion/ion reactions at atmospheric pressure. Ionic products are directly analyzed by mass spectrometry; neutral products are re-ionized using on-line extractive electrospray ionization (EESI) prior to mass analysis. Additionally, "soft landing" is used to collect both neutral and ionic reaction products for further structural elucidation. Derived insights may potentially impact disciplines such as proteomics and synthetic organic chemistry.The work provides research opportunities for both undergraduate and graduate students, including members of underrepresented and disadvantaged groups. Dr. Chen is also actively involved in educational outreach activities, including workshops/seminars for pre-college students to learn about modern instrumental analysis and to develop enthusiasm for scientific research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。分析和表面化学项目支持俄亥俄大学陈浩教授的研究，旨在提高对离子/离子反应机制的洞察力，这对表征包括蛋白质在内的广泛分子很重要。该方法需要在大气压下对气态离子/离子反应的中性和离子产物进行结构分析。离子产物用质谱法直接分析；中性产物在质量分析之前使用在线萃取电喷雾电离（EESI）再电离。此外，“软着陆”用于收集中性和离子反应产物，以进一步阐明结构。由此产生的见解可能会影响蛋白质组学和合成有机化学等学科。这项工作为本科生和研究生提供了研究机会，包括代表性不足和弱势群体的成员。陈博士还积极参与教育推广活动，包括为大学预科学生提供学习现代仪器分析和培养科学研究热情的讲习班/研讨会。