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Chronic exposure to particulate air pollution and progression of subclinical atherosclerosis- Investigation based on the Heinz Nixdorf Recall Study

长期暴露于颗粒空气污染和亚临床动脉粥样硬化的进展——基于 Heinz Nixdorf Recall 研究的调查

基本信息

批准号：
193729231
负责人：
Professorin Dr. Barbara Hoffmann
金额：
--
依托单位：
Institut für Medizinische Statistik, Informatik und Dokumentation
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/193729231?language=en
关键词：
Chronic exposure particulate air pollution

项目摘要

Long-term particulate matter (PM) air pollution and residential exposure to high traffic are linked to the incidence of acute cardiovascular events. It has been proposed that fine PM might have a biologic role in the development of the underlying chronic processes of atherosclerosis, which is supported by animal studies and one prospective study in a highly selected population. The most important finding from the first phase of our study is an association of particulate air pollution with progression of subclinical atherosclerosis in a randomly selected population-based cohort. We found a clear association with the 5-year progression of the left carotid intima media thickness (CIMT) and, in a cross-sectional analysis, with prevalence of carotid plaque. In this renewal proposal, we propose to (1) investigate effects of source-specific PM and individual chemical constituents of PM on the progression of subclinical atherosclerosis. This is of utmost importance for identifying the most harmful elements of urban air pollution. (2) We want to extend the current analysis of long-term air pollution exposure and CIMT to the investigation of progression of calcification in the coronary (CAC) and the thoracic aortic (TAC) vascular bed. Coronary and thoracic aortic calcification might not only be influenced by environmental risk factors in a different way, they also represent different stages of the atherosclerotic disease and predict coronary events better than CIMT. (3) We propose to conduct in depth analyses of gene x environment interactions of genes involved in pathways of atherogenesis to identify relevant biologic mechanisms of PM.We will base our investigations on the Heinz Nixdorf Recall Study. Next to the baseline and the 5-year examination, data from the 10-year examination of CIMT will become available during the project phase. Furthermore, we will be able to use source- and constituent-specific exposure data, applying model calculations that were conducted in the framework of a DFG-project (JO 170/8-1) and from a land use regression model, which was developed in the framework of the EU-ESCAPE project. The results will be of great public health relevance because fine particle exposure is ubiquitous, no safe threshold has been identified yet, the most toxic particle characteristics or components are still unclear, and the outcome is of utmost importance for the incidence of cardiovascular and cerebrovascular disease.

长期颗粒物 (PM) 空气污染和住宅区交通繁忙与急性心血管事件的发生率有关。有人提出，细颗粒物可能在动脉粥样硬化的潜在慢性过程的发展中具有生物学作用，这一点得到了动物研究和一项针对精选人群的前瞻性研究的支持。我们研究第一阶段最重要的发现是，在随机选择的人群队列中，颗粒物空气污染与亚临床动脉粥样硬化的进展存在关联。我们发现左颈动脉内膜中层厚度 (CIMT) 的 5 年进展与颈动脉斑块的患病率存在明显的相关性，并且在横断面分析中也与颈动脉斑块的患病率相关。在这项更新提案中，我们建议 (1) 研究特定来源的 PM 和 PM 的单个化学成分对亚临床动脉粥样硬化进展的影响。这对于识别城市空气污染中最有害的元素至关重要。 (2) 我们希望将当前对长期空气污染暴露和 CIMT 的分析扩展到冠状动脉 (CAC) 和胸主动脉 (TAC) 血管床钙化进展的研究。冠状动脉和胸主动脉钙化不仅可能以不同的方式受到环境危险因素的影响，而且它们还代表动脉粥样硬化疾病的不同阶段，并且比 CIMT 更好地预测冠状动脉事件。 (3)我们建议对参与动脉粥样硬化通路的基因与环境的相互作用进行深入分析，以确定PM的相关生物学机制。我们的研究将基于Heinz Nixdorf Recall研究。除了基线和 5 年检查之外，CIMT 10 年检查的数据将在项目阶段提供。此外，我们将能够使用特定源和特定成分的暴露数据，应用在 DFG 项目 (JO 170/8-1) 框架中进行的模型计算以及在 EU-ESCAPE 项目框架中开发的土地利用回归模型。研究结果将具有重大的公共卫生意义，因为细颗粒物暴露无处不在，尚未确定安全阈值，毒性最强的颗粒特征或成分仍不清楚，而且结果对于心脑血管疾病的发病率至关重要。