Quartz Resonator Array for calorimetric (bio)chemical Sensing Applications

用于量热(生物)化学传感应用的石英谐振器阵列该奖项由2009年美国复苏和再投资法案(公共法律111-5)资助。这项研究的目标是设计并展示一种多功能、高像素密度、量热(生物)化学传感器阵列，该阵列由温度敏感的微机械石英晶体谐振器组成。该方法是将微机械生化反应室放置在靠近石英谐振器阵列的位置，并通过窄间隙中的环境气体辐射和传导将来自反应室的热量耦合到石英谐振器。石英的近似性和极高的红外吸收系数使该系统成为一种非常灵敏的量热计设计。所提出的QCM阵列将是与反应室集成的平面量热生物传感器阵列的独特新演示。由于石英微加工工艺的最新发展，阵列级别的温度灵敏度达到前所未有的10-5°C是可能的，这为阵列级(生物)化学传感应用提供了一个独特的机会。这项工作的最终目标是创建一种手持或台式多分析传感器系统，其中带有集成生物反应器的石英谐振器阵列可以作为一次性的、易于更换的墨盒投入使用。拟议的传感系统将在生化分析、临床诊断、实验室仪器和国土安全方面得到应用。此外，它还将用于与生物分子生长、构象和反应热力学有关的生化过程和现象的基本实时研究。将在本科生和研究生一级开设关于生物传感器和生物材料的跨学科课程和研究活动。校园内的各种NSF-REU和暑期研究机会计划(SROP)将被用来吸引代表性不足的群体。

Quartz Resonator Array for Calorimetric (Bio)Chemical Sensing ApplicationsThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The objective of this research to design, and demonstrate a versatile, high pixel density, calorimetric (bio)chemical sensor array from temperature sensitive micromachined quartz crystal resonators. The approach is to locate micromachined biochemical reaction chambers in close proximity to the quartz resonator array and couple the heat from the reaction chamber to the quartz resonator via radiation and conduction through ambient gas in the narrow gap. The close proximity and the extremely high infrared absorption coefficient of quartz renders this system into a very sensitive calorimeter design.The proposed QCM array will be unique new demonstration of a planar calorimetric biosensor array integrated with reaction chamber. The unprecedented temperature sensitivity of 10-5 °C at array level is only possible due to recent developments in quartz micromachining processes and offers a unique opportunity for array level (bio)chemical sensing applications.The ultimate aim of this work is to create a handheld or desktop multianalyte sensor system in which the quartz resonator arrays with the integrated bioreactors can be dropped in as disposable, easy to swap cartridges. The proposed sensing system will find applications in biochemical assays, clinical diagnostics, laboratory instrumentation, and homeland security. In addition, it will be used for fundamental real-time investigations of biochemical processes and phenomena relating to biomolecular growth, conformations, and reaction thermodynamics. Interdisciplinary courses and research activities on biosensors and biomaterials will be developed at undergraduate and graduate levels. The various NSF-REU and Summer Research Opportunity Program (SROP) on campus will be used to attract under-represented groups.