Quartz Resonator Array for calorimetric (bio)chemical Sensing Applications

石英谐振器阵列用于量热（生物）化学传感应用该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。本研究的目标是设计和展示一个多功能，高像素密度，量热（生物）化学传感器阵列，温度敏感的微机械石英晶体谐振器。该方法是将微加工的生化反应室定位在紧邻石英谐振器阵列的位置，并通过辐射和传导将来自反应室的热量耦合到石英谐振器，并通过狭窄间隙中的环境气体。石英的近距离和极高的红外吸收系数使该系统成为一个非常灵敏的量热计设计。所提出的QCM阵列将是一个独特的平面量热生物传感器阵列与反应室集成的新演示。由于石英微机械加工工艺的最新发展，阵列级的温度灵敏度达到了前所未有的10-5 °C，这为阵列级（生物）化学传感应用提供了独特的机会。这项工作的最终目的是创建一个手持式或台式多分析物传感器系统，其中集成了生物反应器的石英谐振器阵列可以作为一次性的，易于交换的盒。所提出的传感系统将在生化分析，临床诊断，实验室仪器和国土安全中找到应用。此外，它还将用于与生物分子生长，构象和反应热力学相关的生化过程和现象的基本实时调查。将在本科生和研究生阶段开设关于生物传感器和生物材料的跨学科课程和开展研究活动。校园内的各种NSF-REU和夏季研究机会计划（SROP）将用于吸引代表性不足的群体。

Quartz Resonator Array for Calorimetric (Bio)Chemical Sensing ApplicationsThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The objective of this research to design, and demonstrate a versatile, high pixel density, calorimetric (bio)chemical sensor array from temperature sensitive micromachined quartz crystal resonators. The approach is to locate micromachined biochemical reaction chambers in close proximity to the quartz resonator array and couple the heat from the reaction chamber to the quartz resonator via radiation and conduction through ambient gas in the narrow gap. The close proximity and the extremely high infrared absorption coefficient of quartz renders this system into a very sensitive calorimeter design.The proposed QCM array will be unique new demonstration of a planar calorimetric biosensor array integrated with reaction chamber. The unprecedented temperature sensitivity of 10-5 °C at array level is only possible due to recent developments in quartz micromachining processes and offers a unique opportunity for array level (bio)chemical sensing applications.The ultimate aim of this work is to create a handheld or desktop multianalyte sensor system in which the quartz resonator arrays with the integrated bioreactors can be dropped in as disposable, easy to swap cartridges. The proposed sensing system will find applications in biochemical assays, clinical diagnostics, laboratory instrumentation, and homeland security. In addition, it will be used for fundamental real-time investigations of biochemical processes and phenomena relating to biomolecular growth, conformations, and reaction thermodynamics. Interdisciplinary courses and research activities on biosensors and biomaterials will be developed at undergraduate and graduate levels. The various NSF-REU and Summer Research Opportunity Program (SROP) on campus will be used to attract under-represented groups.