I-Corps: Calorimetric Diagnostic Instrument for Acute Kidney Infection Monitoring

I-Corps：用于监测急性肾脏感染的量热诊断仪器

• 批准号: 1544180
• 负责人: Srinivas Tadigadapa
• 金额: $ 5万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1544180&HistoricalAwards=false
• 关键词: Corps; Calorimetric; Diagnostic; Instrument; Acute

Acute kidney injury (AKI) occurs in 5-7% of hospitalized patients and results in a mortality rate of about 50%. A particularly disturbing feature has been the inability since the mid-1960s to substantially lower mortality rates in AKI. The financial costs of AKI are estimated to be 8 billion dollars per year, or about $130,000 per life-year saved. It is unlikely that this high mortality and associated cost will be reduced until better tools for the early diagnosis of renal injury are available. Accordingly, a critical need exists to develop clinically efficient means for the detection of early acute renal failure. This NSF I-Corps project aims to explore and evaluate the commercialization potential of the "Calorimetric Diagnostic Instrument for Acute Kidney Infection" that has been engineered from an earlier NSF funded research proposal. Specifically, the proposed instrument involves a quartz resonator based thermal biosensor concept into a biomedical instrumentation system for continuous monitoring of kidney function based on the measurement of urinary creatinine excretion.Using the quartz based calorimetric device, the team has developed a biosensing system to quantify the concentration of creatinine in urine in a near continuous fashion. The biosensor consists of miniaturized pumps, quartz resonator sensor, electronics, and a replicable fluidic cartridge packed with immobilized enzyme. The idea of having the sensor and its electronics separated from the analyte of interest not only provides advantages in measurements but allows for significant cost savings. Rather, than having to throw away expensive sensors intertwined with the immobilized enzyme, the proposed operational scheme allows for the sensor system to be used indefinitely with only the fluidic tubing containing immobilized enzyme being easily swapped. Hence this design lends itself to a commercialization model akin to the glucose sensor. The team plans to summarize and incorporate the various suggestions from customer interviews during the I-Corps program to build a beta-prototype.

急性肾脏损伤（AKI）发生在5-7％的住院患者中，死亡率约为50％。一个特别令人不安的特征是自1960年代中期以来一直无法降低AKI的死亡率。 AKI的财务成本估计为每年80亿美元，每年节省的年龄约为130,000美元。直到获得更好的早期诊断肾脏损伤的工具之前，这种高死亡率和相关成本不可能降低。因此，存在临床高效手段以检测早期急性肾衰竭的临床高效手段。该NSF I-Corps项目旨在探索和评估“急性肾脏感染的量热诊断仪器”的商业化潜力，该工具是由NSF早期资助的研究建议设计的。具体而言，提出的仪器涉及基于石英谐振器的热生物传感器概念进入生物医学仪器系统，以基于测量尿肌氨酸排泄的测量，用于连续监测肾脏功能。使用石英钙化器械，该团队开发了一种生物传感系统，开发了一种生物传感器，以量化近乎蛋白素的浓度连续的时尚。生物传感器由微型泵，石英谐振传感器，电子设备和富含固定酶的可复制液体墨盒组成。将传感器及其电子设备与感兴趣分析物分开的想法不仅在测量中提供了优势，而且可以节省大量成本。相反，提议的操作方案不必扔掉与固定酶交织在一起的昂贵传感器，因此只有仅包含含有固定酶的流体管，可以轻松地使用传感器系统。因此，这种设计将自己具有类似于葡萄糖传感器的商业化模型。该团队计划在I-Corps计划期间总结并结合客户访谈中的各种建议，以构建Beta-Prototype。