RUI: Catalysis Using Decarboxylation of Carboxymethylbetaine Functionality

RUI：利用羧甲基甜菜碱官能团脱羧的催化

• 批准号: 0957482
• 负责人: David Forbes
• 金额: $ 24.7万
• 依托单位: University of South Alabama
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957482&HistoricalAwards=false
• 关键词: RUI; Catalysis; Using; Decarboxylation; Carboxymethylbetaine

The Chemical Catalysis Program supports Professor David Forbes at the University of South Alabama for a research project that will develop a method of creating sulfur ylides that are useful in forming carbon-carbon bonds and three-membered rings. This is a commonly used reaction in organic synthesis but is usually difficult to get good yields consistently. Professor Forbes has proposed a process that overcomes this limitation, and has found a way to improve reactions that have been reported in this area, which could lead to the development of new processes. Increased understanding of these key processes would provide a new method of high utility that can be used in a wide range of organic syntheses. The major goal of the proposal is to render this methodology catalytic in the sulfide promoter, making the methodology more atom efficient and opening avenues for chiral catalysis. This research is likely to lead to processes that are of great value to synthetic chemists and will have a significant impact on the chemistry community.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Forbes will perform research that addresses a long-standing problem in the potentially useful area of organocatalytic synthesis: that of catalytic sulfide-mediated methylene transfer using non-dangerous chemicals. This versatile and potentially environmentally benign methodology would have industrial applications of economic and environmental benefit. Broader impacts involve the training of undergraduate students in chemistry, outreach to local high school chemistry teachers through the Alabama Science in Motion (ASIM) Program, and ongoing collaborations, especially with industry.

化学催化计划支持南亚拉巴马大学的大卫福布斯教授进行一项研究项目，该项目将开发一种制造硫叶立德的方法，该方法可用于形成碳-碳键和三元环。这是有机合成中常用的反应，但通常很难获得一致的好收率。福布斯教授提出了一种克服这一限制的方法，并找到了一种改进该领域已报道的反应的方法，这可能导致新方法的开发。增加对这些关键过程的理解将提供一种高实用性的新方法，可用于广泛的有机合成。该提案的主要目标是使该方法在硫化物促进剂中具有催化性，使该方法更具原子效率并为手性催化开辟途径。这项研究很可能会导致对合成化学家有很大价值的过程，并将对化学界产生重大影响。在美国国家科学基金会化学部化学催化计划的支持下，福布斯博士将进行研究，解决有机催化合成潜在有用领域的一个长期存在的问题：即使用非危险化学品的催化硫化物介导的亚甲基转移。这种通用的和潜在的环境友好的方法将具有经济和环境效益的工业应用。更广泛的影响涉及化学本科生的培训，通过亚拉巴马科学运动（ASIM）计划与当地高中化学教师的联系，以及正在进行的合作，特别是与工业界的合作。