RUI: Catalysis Using Decarboxylation of Carboxymethylbetaine Functionality

化学催化计划支持南阿拉巴马大学的大卫·福布斯教授的一个研究项目，该项目将开发一种创建硫叶立德的方法，这种方法有助于形成碳-碳键和三元环。这是有机合成中常用的反应，但通常很难得到稳定的高产率。福布斯教授提出了一种克服这一限制的方法，并找到了一种方法来改善这一领域已报道的反应，这可能会导致新过程的开发。增加对这些关键过程的了解将提供一种新的高实用性的方法，可用于广泛的有机合成。该提案的主要目标是使这一方法在硫化物促进剂中具有催化作用，使该方法更具原子效率，并为手性催化开辟道路。这项研究可能导致对合成化学家具有重要价值的过程，并将对化学界产生重大影响。在国家科学基金会化学部化学催化计划的支持下，福布斯博士将进行研究，以解决有机催化合成潜在有用领域中的一个长期存在的问题：使用非危险化学品的催化硫化物介导的亚甲基转移。这种多才多艺、可能对环境无害的方法将具有经济和环境效益的工业应用。更广泛的影响包括对本科生进行化学培训，通过阿拉巴马州移动科学(ASIM)计划接触当地高中化学教师，以及持续的合作，特别是与行业的合作。

The Chemical Catalysis Program supports Professor David Forbes at the University of South Alabama for a research project that will develop a method of creating sulfur ylides that are useful in forming carbon-carbon bonds and three-membered rings. This is a commonly used reaction in organic synthesis but is usually difficult to get good yields consistently. Professor Forbes has proposed a process that overcomes this limitation, and has found a way to improve reactions that have been reported in this area, which could lead to the development of new processes. Increased understanding of these key processes would provide a new method of high utility that can be used in a wide range of organic syntheses. The major goal of the proposal is to render this methodology catalytic in the sulfide promoter, making the methodology more atom efficient and opening avenues for chiral catalysis. This research is likely to lead to processes that are of great value to synthetic chemists and will have a significant impact on the chemistry community.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Forbes will perform research that addresses a long-standing problem in the potentially useful area of organocatalytic synthesis: that of catalytic sulfide-mediated methylene transfer using non-dangerous chemicals. This versatile and potentially environmentally benign methodology would have industrial applications of economic and environmental benefit. Broader impacts involve the training of undergraduate students in chemistry, outreach to local high school chemistry teachers through the Alabama Science in Motion (ASIM) Program, and ongoing collaborations, especially with industry.