SBIR Phase I: Improved Photoionization Source for LC/MS Analysis for Food Safety

SBIR 第一阶段：用于食品安全 LC/MS 分析的改进光电离源

• 批准号: 1013488
• 负责人: Jack Syage
• 金额: $ 9.86万
• 依托单位: SYAGEN TECHNOLOGY INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1013488&HistoricalAwards=false
• 关键词: SBIR; Phase; Improved; Photoionization; Source

This Small Business Innovation Research (SBIR) Phase I project will lead to a new technology for analyzing contaminants in food substances. This is an extremely challenging analytical problem due to the vast range of contaminants that need to be screened and the complex and varied matrices of different food commodities. The state-of-the-art in analysis is based on electrospray ionization (ESI) and liquid chromatography mass spectrometry (LC-MS). Unfortunately for environmental and biological samples ESI suffers several limitations including matrix ion suppression, poor dynamic range, and inability to ionize nonpolar compounds. We will significantly improve on the analytical accuracy of food contaminants by implementing atmospheric pressure photoionization (APPI), which allows much better control of the undesirable ion-molecule chemistry that plagues ESI. We will test combined ESI/APPI configurations and modes of operation and achieve critical control of ion-molecule interactions from dual ionization. A total system approach will be investigated to develop the optimum technology solution.The broader/commercial impacts of this research are: (i) significantly improved analysis of harmful compounds in foods providing significant societal benefit in terms of health, well being, and lower healthcare costs, (ii) significant new revenue to Syagen through increased sales off APPI-based products, (iii) improve the technical competitiveness of the U.S. in food safety for which Europe currently leads, and (iv) increase the value proposition for expensive analytical instrumentation by improving the quality and speed of chemical analyses.

这个小型企业创新研究（SBIR）第一阶段项目将导致一种新的技术，用于分析食品中的污染物。这是一个极具挑战性的分析问题，因为需要筛选的污染物范围很广，而且不同食品的基质复杂多样。最先进的分析方法是基于电喷雾电离（ESI）和液相色谱质谱（LC-MS）。不幸的是，对于环境和生物样品，ESI受到几个限制，包括基质离子抑制，动态范围差，以及无法识别非极性化合物。通过实施大气压光电离（APPI），我们将显著提高食品污染物的分析准确性，这可以更好地控制困扰ESI的不良离子分子化学。我们将测试组合ESI/APPI配置和操作模式，并实现双电离离子分子相互作用的关键控制。将研究一个整体系统方法，以开发最佳的技术解决方案。这项研究的更广泛/商业影响是：（i）显著改善对食品中有害化合物的分析，在健康、福祉和降低医疗成本方面提供显著的社会效益，（ii）通过增加基于APP的产品的销售，为Syagen带来显著的新收入，（iii）提高美国在食品安全方面的技术竞争力，而欧洲目前在这方面处于领先地位;（iv）通过提高化学分析的质量和速度，提高昂贵分析仪器的价值主张。