Role of ubiquitin in plant cell death

泛素在植物细胞死亡中的作用

• 批准号: 19759870
• 负责人: Professor Dr. Andreas Bachmair
• 金额: --
• 依托单位: Max F. Perutz Laboratories
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/19759870?language=en
• 关键词: Role; ubiquitin; plant; cell; death

Programmed cell death in plants occurs in at least three contexts. Firstly, developmental processes such as formation of vascular tissue employ cell death to shape plant tissues. Secondly, defense against pathogens frequently involves the hypersensitive response, a rapid form of programmed cell death. Thirdly, programmed cell death in the form of senescence serves to mobilize nutrients from older plant parts to growing parts and to seeds. All of these processes are incompletely understood, and manipulation of their induction and extent would provide immediate benefits to agriculture. The ubiquitin proteasome pathway is the major route for destruction of unwanted proteins in the eukaryotic cell. In animals, the pathway has a pivotal role in regulating programmed cell death. We have previously demonstrated that the pathway is also involved in plant cell death processes. In this application, we propose to investigate connections between ubiquitin and plant cell death at the molecular level, using mutants and assay systems developed in our preliminary work.

植物中的程序性细胞死亡至少发生在三种情况下。首先，维管组织形成等发育过程利用细胞死亡来塑造植物组织。其次，对病原体的防御经常涉及过敏反应，这是一种快速的程序性细胞死亡形式。第三，衰老形式的程序性细胞死亡有助于将营养物质从较老的植物部分转移到生长部分和种子。所有这些过程尚不完全清楚，对其诱导和程度的操纵将为农业带来立竿见影的好处。泛素蛋白酶体途径是破坏真核细胞中不需要的蛋白质的主要途径。在动物中，该途径在调节程序性细胞死亡中起着关键作用。我们之前已经证明该途径也参与植物细胞死亡过程。在本申请中，我们建议使用我们前期工作中开发的突变体和测定系统，在分子水平上研究泛素与植物细胞死亡之间的联系。