Spatial and Temporal Mapping of the Suprachiasmatic Nucleus Transcriptome

视交叉上核转录组的时空作图

基本信息

  • 批准号:
    1021957
  • 负责人:
  • 金额:
    $ 37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-01 至 2014-06-30
  • 项目状态:
    已结题

项目摘要

Biological rhythms in physiology and behavior, such as the sleep/wake cycle, are regulated by an internal biological clock located at the base of the brain in the hypothalamus. This clock (located in a brain region called the suprachiasmatic nucleus, or SCN) has a well-defined structure that has many features that are conserved across mammalian species. The ways in which the complexities of this brain region contribute to the function of organisms are not fully understood. The SCN appears to have regions devoted to processing sensory input and generating rhythmic output. Using a gene-expression based approach, this project aims to distinguish the functions of these subregions of the clock and how they contribute to the overall function of the organism. It is anticipated that the results of these experiments will reveal novel information about how the structure of the biological clock relates to its function, and how different portions of the clock carry out different functions. This project will significantly impact our current understanding of clock function, which has common mechanisms in nearly all animals. Gene expression data will be deposited in the National Library of Medicine's Gene Expression Omnibus where it will be available to other researchers and the public.
生理和行为的生物节律,如睡眠/觉醒周期,由位于下丘脑大脑底部的内部生物钟调节。 这个生物钟(位于大脑中称为视交叉上核(SCN)的区域)具有明确的结构,具有许多哺乳动物物种中保守的特征。 这个大脑区域的复杂性对生物体功能的贡献方式尚未完全了解。 SCN似乎有专门处理感觉输入和产生节奏输出的区域。 使用基于基因表达的方法,该项目旨在区分这些时钟子区域的功能以及它们如何对生物体的整体功能做出贡献。 预计这些实验的结果将揭示生物钟的结构如何与其功能相关的新信息,以及生物钟的不同部分如何执行不同的功能。 这个项目将极大地影响我们目前对生物钟功能的理解,生物钟功能在几乎所有动物中都有共同的机制。 基因表达数据将存放在国家医学图书馆的基因表达综合资料库中,供其他研究人员和公众使用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Eric Mintz其他文献

Correction to: A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January – June 2015
  • DOI:
    10.1186/s12889-017-4801-y
  • 发表时间:
    2017-10-18
  • 期刊:
  • 影响因子:
    3.600
  • 作者:
    Steven Ndugwa Kabwama;Lilian Bulage;Fred Nsubuga;Gerald Pande;David Were Oguttu;Richardson Mafigiri;Christine Kihembo;Benon Kwesiga;Ben Masiira;Allen Eva Okullo;Henry Kajumbula;Joseph KB Matovu;Issa Makumbi;Milton Wetaka;Sam Kasozi;Simon Kyazze;Melissa Dahlke;Peter Hughes;Juliet Nsimire Sendagala;Monica Musenero;Immaculate Nabukenya;Vincent R. Hill;Eric Mintz;Janell Routh;Gerardo Gómez;Amelia Bicknese;Bao-Ping Zhu
  • 通讯作者:
    Bao-Ping Zhu

Eric Mintz的其他文献

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{{ truncateString('Eric Mintz', 18)}}的其他基金

Implementation Project: Data Driven, Engagement Based, Adaptive Learning, Growth Mindset Pedagogy Informed Course Redesign with Early Research Experiences for STEM Student Success
实施项目:数据驱动、基于参与、适应性学习、成长心态教育学的课程重新设计以及 STEM 学生成功的早期研究经验
  • 批准号:
    1912256
  • 财政年份:
    2019
  • 资助金额:
    $ 37万
  • 项目类别:
    Continuing Grant
Data Driven, Engagement Based, Adaptive Learning, Growth Mindset Pedagogy Informed Course Redesign with Early Research Experiences for STEM Student Success
数据驱动、基于参与、适应性学习、成长心态教学法以及早期研究经验的课程重新设计,促进 STEM 学生的成功
  • 批准号:
    1818682
  • 财政年份:
    2018
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant
Building CAU Capacity to Prepare STEM Teachers for High Need K-12 School Districts
建设中国农业大学为高需求 K-12 学区培养 STEM 教师的能力
  • 批准号:
    1340039
  • 财政年份:
    2013
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant
MRI: Acquisition of Equipment for a Microgenomics Facility
MRI:为微观基因组学设施购置设备
  • 批准号:
    0320858
  • 财政年份:
    2003
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant
Renovation of the Biology Building Into The Environmental Sciences Research Laboratory
生物楼改造为环境科学研究实验室
  • 批准号:
    9214451
  • 财政年份:
    1995
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant
Thermal Analysis System for Characterization and Evaluation of High Performance Polymers & Ceramics
用于高性能聚合物表征和评估的热分析系统
  • 批准号:
    9253016
  • 财政年份:
    1992
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant
Investigation of Bridged Organometallic Complexes on Metal Oxide Supports
金属氧化物载体上桥联有机金属配合物的研究
  • 批准号:
    9014260
  • 财政年份:
    1990
  • 资助金额:
    $ 37万
  • 项目类别:
    Standard Grant

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NCS-FO A transformative approach for mapping spatial and temporal dynamics of anterior cingulate function in humans
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High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
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  • 批准号:
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  • 财政年份:
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  • 项目类别:
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