HPL-Pathway Mediated Stress Signaling Networks in Plants

Katayoon Dehesh IOS-1036491 HPL途径介导的植物应激信号网络作为固着生物，植物必须科普许多非生物和生物应激。 由于这些压力，作物产量损失很大。 为了对抗环境胁迫，植物利用许多不同的机制，包括基于脂肪酸的途径来发出胁迫响应的信号，最终导致胁迫耐受性。一种这样的途径是负责将含氧脂肪酸裂解成一系列代谢物的过氧化氢裂解酶（HPL）途径。 植物对HPL衍生的代谢物的感知和响应是公认的，但是负责这些代谢物的作用机制的潜在机制仍然是难以捉摸的。阐明这些机制是识别介导激活必要的适应性反应的信号通路的核心，从而增强对环境挑战的耐受性。该研究计划利用尖端的分子，生物化学和遗传方法的组合，使用植物模型系统，以提供重要的洞察力到以前未表征的HPL途径介导的压力信号网络在农业上重要的压力，如干旱和干旱诱导的缺氧引起的非生物胁迫的植物中的机制基础。了解HPL同源代谢物在植物对非生物胁迫的耐受性中的作用将具有两个主要影响。教育影响是通过：（1）创建一个强大的和多方面的计划，以指导学者在国家的最先进的跨学科研究;（2）扩大努力，以招募代表性不足的少数民族学生;（3）为高中学生和教师提供暑期实习机会，以及大学生。广泛的社会影响，预计通过潜在的发现新的组件与潜在的利用生物技术应用，旨在提高农业作物的非生物胁迫的耐受性。

Katayoon Dehesh IOS-1036491HPL-pathway mediated stress signaling networks in plantsAs sessile organisms plants must cope with numerous abiotic and biotic stresses. As a result of these stresses there are substantial losses in crop yield. To counteract environmental stresses plants utilize a number of different mechanisms including fatty acid based pathways to signal for a stress response, ultimately leading to stress tolerance. One such a pathway is HYDROPEROXIDE LYASE (HPL) pathway responsible for the cleavage of oxygenated fatty acids into a range of metabolites. It is well established that plants perceive and respond to HPL-derived metabolites, but the underlying mechanisms responsible for mechanism of action of these metabolites, have remained elusive. Elucidation of these mechanisms is central to the identification of signaling pathways mediating the activation of necessary adaptive responses; thereby enhanced tolerance to environmental challenges. This research program exploits a combination of cutting edge molecular, biochemical and genetic approaches using a plant model system in order to provide significant insights into the mechanistic basis of a previously uncharacterized HPL-pathway mediated stress signaling networks in plants in agriculturally important stresses caused by abiotic stresses such as draught and flooding-induced hypoxia. Understanding of the role of HPL cognate metabolites in the plant tolerance to abiotic stresses will have two major impacts. Educational impacts are through: (1) creating a strong and multidimensional program to mentor scholars in state-of-the-art interdisciplinary research; (2) extended efforts to recruit underrepresented minority students; (3) providing summer internship opportunities for high school students and teachers, and college students. Broad social impacts are expected through potential discovery of novel components with potential utilization in biotechnological applications geared towards enhanced tolerance to abiotic stresses in agronomic crops.