HPL-Pathway Mediated Stress Signaling Networks in Plants

Katayoon Dehesh IOS-1036491HPL途径介导的植物中的胁迫信号网络植物作为固着生物，必须应对大量的非生物和生物胁迫。由于这些压力，农作物产量有很大损失。为了抵消环境压力，植物利用许多不同的机制，包括基于脂肪酸的途径来发出胁迫反应的信号，最终导致胁迫耐受性。一个这样的途径是氢过氧化氢裂解酶(HPL)途径，负责将含氧脂肪酸裂解成一系列代谢物。众所周知，植物感知和响应HPL衍生的代谢物，但这些代谢物作用机制的潜在机制仍然难以捉摸。这些机制的阐明对于识别信号通路至关重要，这些信号通路介导了必要的适应性反应的激活，从而增强了对环境挑战的耐受性。这项研究计划利用先进的分子、生化和遗传方法的组合，使用植物模型系统，以提供重要的洞察力，以了解在由干旱和淹水诱导的低氧等非生物胁迫引起的农业上重要的胁迫下，植物中以前未描述的HPL途径介导的胁迫信号网络的机制基础。了解HPL同源代谢物在植物对非生物胁迫耐受性中的作用将有两个主要影响。教育影响是通过：(1)创建一个强大和多维的计划，指导最先进的跨学科研究的学者；(2)扩大努力，招募代表人数较少的少数族裔学生；(3)为高中生和教师以及大学生提供暑期实习机会。潜在的新成分的发现有望产生广泛的社会影响，这些新成分有可能用于生物技术应用，以提高农艺作物对非生物胁迫的耐受性。

Katayoon Dehesh IOS-1036491HPL-pathway mediated stress signaling networks in plantsAs sessile organisms plants must cope with numerous abiotic and biotic stresses. As a result of these stresses there are substantial losses in crop yield. To counteract environmental stresses plants utilize a number of different mechanisms including fatty acid based pathways to signal for a stress response, ultimately leading to stress tolerance. One such a pathway is HYDROPEROXIDE LYASE (HPL) pathway responsible for the cleavage of oxygenated fatty acids into a range of metabolites. It is well established that plants perceive and respond to HPL-derived metabolites, but the underlying mechanisms responsible for mechanism of action of these metabolites, have remained elusive. Elucidation of these mechanisms is central to the identification of signaling pathways mediating the activation of necessary adaptive responses; thereby enhanced tolerance to environmental challenges. This research program exploits a combination of cutting edge molecular, biochemical and genetic approaches using a plant model system in order to provide significant insights into the mechanistic basis of a previously uncharacterized HPL-pathway mediated stress signaling networks in plants in agriculturally important stresses caused by abiotic stresses such as draught and flooding-induced hypoxia. Understanding of the role of HPL cognate metabolites in the plant tolerance to abiotic stresses will have two major impacts. Educational impacts are through: (1) creating a strong and multidimensional program to mentor scholars in state-of-the-art interdisciplinary research; (2) extended efforts to recruit underrepresented minority students; (3) providing summer internship opportunities for high school students and teachers, and college students. Broad social impacts are expected through potential discovery of novel components with potential utilization in biotechnological applications geared towards enhanced tolerance to abiotic stresses in agronomic crops.