HPL-Pathway Mediated Stress Signaling Networks in Plants

植物中hpl通路介导的胁迫信号网络作为一种无根生物，植物必须应对大量的非生物和生物胁迫。由于这些压力，作物产量损失很大。为了对抗环境胁迫，植物利用多种不同的机制，包括脂肪酸为基础的途径来发出胁迫反应的信号，最终导致抗逆性。其中一种途径是氢过氧化物裂解酶（HPL）途径，它负责将氧化脂肪酸裂解成一系列代谢物。植物对hpl衍生的代谢物的感知和反应是公认的，但这些代谢物的作用机制的潜在机制仍然是未知的。阐明这些机制是识别介导必要适应性反应激活的信号通路的核心；从而增强了对环境挑战的容忍度。本研究项目利用尖端分子、生化和遗传方法的结合，利用植物模型系统，为在干旱和洪水引起的缺氧等非生物胁迫引起的农业重要胁迫下，植物中先前未被表征的hpl途径介导的胁迫信号网络的机制基础提供重要的见解。了解HPL同源代谢物在植物对非生物胁迫的耐受性中的作用将有两个主要影响。教育影响是通过：(1)创建一个强大的、多维的项目来指导学者进行最先进的跨学科研究；(2)加大力度招收代表性不足的少数民族学生；(3)为高中生、教师和大学生提供暑期实习机会。广泛的社会影响预期通过潜在的新成分的发现与潜在的利用在生物技术应用面向提高农业作物对非生物胁迫的耐受性。

Katayoon Dehesh IOS-1036491HPL-pathway mediated stress signaling networks in plantsAs sessile organisms plants must cope with numerous abiotic and biotic stresses. As a result of these stresses there are substantial losses in crop yield. To counteract environmental stresses plants utilize a number of different mechanisms including fatty acid based pathways to signal for a stress response, ultimately leading to stress tolerance. One such a pathway is HYDROPEROXIDE LYASE (HPL) pathway responsible for the cleavage of oxygenated fatty acids into a range of metabolites. It is well established that plants perceive and respond to HPL-derived metabolites, but the underlying mechanisms responsible for mechanism of action of these metabolites, have remained elusive. Elucidation of these mechanisms is central to the identification of signaling pathways mediating the activation of necessary adaptive responses; thereby enhanced tolerance to environmental challenges. This research program exploits a combination of cutting edge molecular, biochemical and genetic approaches using a plant model system in order to provide significant insights into the mechanistic basis of a previously uncharacterized HPL-pathway mediated stress signaling networks in plants in agriculturally important stresses caused by abiotic stresses such as draught and flooding-induced hypoxia. Understanding of the role of HPL cognate metabolites in the plant tolerance to abiotic stresses will have two major impacts. Educational impacts are through: (1) creating a strong and multidimensional program to mentor scholars in state-of-the-art interdisciplinary research; (2) extended efforts to recruit underrepresented minority students; (3) providing summer internship opportunities for high school students and teachers, and college students. Broad social impacts are expected through potential discovery of novel components with potential utilization in biotechnological applications geared towards enhanced tolerance to abiotic stresses in agronomic crops.