MRI: Acquisition of a MALDI TOF-TOF Mass Spectrometer

MRI：购买 MALDI TOF-TOF 质谱仪

• 批准号: 1040016
• 负责人: Daniel Talham
• 金额: $ 27.38万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1040016&HistoricalAwards=false
• 关键词: MRI; Acquisition; MALDI; TOF; Mass

With this award co-funded by the Division of Chemistry and the Major Research Instrumentation (MRI) program, Professor Daniel R. Talham and colleagues John R. Reynolds, K. B. Wagener and Stephen A. Miller from the University of Florida and Kevin D. Belfield of the University of Central Florida will acquire a matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometer (MALDI TOF-TOF MS). The award will enhance research, training and education at all levels, especially in polymer science, chemical imaging, biomarker discovery and natural products research. Specific areas of research to be investigated include studies of acyclic diene metathesis of precision olefins, multiphoton absorbing supramolecular photonic materials, biodegradable plastics, conjugated donor-acceptor polymers, peptide-based natural products, and bioanalytical applications of aptamer-based platforms. Mass spectrometers (MS) are used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Matrix-assisted laser desorption ionization (MALDI) is a technique for preparing the sample to be ionized by a laser before injection into the mass spectrometer. The time of flight (TOF) mass analyzer has high sensitivity and mass accuracy to assist the analyses and interpretation of the resultant data. This open access instrument will be available to all at the Universities of Florida and Central Florida and as a service for external user groups throughout the Southeast and Puerto Rico, including several at Florida A&M University. It will provide training to undergraduate, graduate and post doctoral students in state-of-the-art mass spectrometry usage.

该奖项由化学部和主要研究仪器（MRI）计划共同资助，丹尼尔R。Talham和他的同事John R.雷诺兹，K。B。Wagener和Stephen A.来自佛罗里达大学的米勒和凯文D.中佛罗里达大学的贝尔菲尔德将获得一台基质辅助激光解吸电离串联飞行时间质谱仪（MALDI TOF-TOF MS）。该奖项将加强各级研究，培训和教育，特别是在聚合物科学，化学成像，生物标志物发现和天然产物研究。 具体的研究领域包括精密烯烃的无环二烯复分解研究、多光子吸收超分子光子材料、生物降解塑料、共轭供体-受体聚合物、基于肽的天然产物以及基于适体平台的生物分析应用。质谱仪（MS）用于通过测量样品中的分子成分在它们被电离并被质谱仪检测之后的质量来识别样品的化学组成。 基质辅助激光解吸电离（MALDI）是一种用于在注入质谱仪之前制备待通过激光电离的样品的技术。 飞行时间（TOF）质量分析仪具有高灵敏度和质量精度，以帮助分析和解释所得数据。 这种开放获取工具将提供给所有在佛罗里达和中央佛罗里达大学，并作为整个东南部和波多黎各，包括几个在佛罗里达A M大学的外部用户组的服务。 它将为本科生、研究生和博士后学生提供最先进的质谱使用方面的培训。